Circulating Progenitor Cells and Cognitive Impairment in Men and Women with Coronary Artery Disease.
Circulating Progenitor Cells and Cognitive Impairment in Men and Women with Coronary Artery Disease.
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DOI：
10.3233/jad-191063
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Vaccarino V
中科院分区：
文献类型：
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作者：
Moazzami K;Wittbrodt MT;Lima BB;Kim JH;Hammadah M;Ko YA;Obideen M;Abdelhadi N;Kaseer B;Gafeer MM;Nye JA;Shah AJ;Ward L;Raggi P;Waller EK;Bremner JD;Quyyumi AA;Vaccarino V
循环祖细胞（CPC）与健康成人的记忆功能和认知障碍有关。然而，目前尚不清楚这种关联是否也存在于冠状动脉疾病（CAD）患者中。评估CAD患者中CPC与记忆表现之间的关系。我们使用韦氏记忆量表-IV的言语和视觉记忆子测验以及连线测验A和B部分评估了509例CAD患者的认知功能。用流式细胞术将CPC计数为CD 45 med/CD 34+血液单核细胞，这些细胞共表达代表造血和内皮祖细胞富集的群体的其他表位。在调整人口统计学和心血管危险因素后，较低的内皮祖细胞计数与较低的视觉和文字记忆评分独立相关（p均< 0.05）。这种关联的程度与种族存在显著的相互作用（p < 0.01），使得文字记忆评分与内皮祖细胞亚群的关联存在于黑人中，但不存在于非黑人参与者中。与造血祖细胞富集细胞或连线试验无相关性。循环内皮祖细胞数量减少与CAD患者的认知功能障碍相关，表明修复/再生过程在维持认知状态中具有保护作用。与非黑人CAD参与者相比，黑人的言语记忆功能受损与较低的CPC计数更密切相关。旨在提高再生能力的策略是否会改善认知需要进一步研究。
Circulating progenitor cells (CPC) have been associated with memory function and cognitive impairment in healthy adults. However, it is unclear whether such associations also exist in patients with coronary artery disease (CAD). To assess the association between CPCs and memory performance among individuals with CAD. We assessed cognitive function in 509 patients with CAD using the verbal and visual Memory subtests of the Wechsler memory scale-IV and the Trail Making Test parts A and B. CPCs were enumerated with flow cytometry as CD45med/CD34+ blood mononuclear cells, those co-expressing other epitopes representing populations enriched for hematopoietic and endothelial progenitors. After adjusting for demographic and cardiovascular risk factors, lower number of endothelial progenitor cell counts were independently associated with lower visual and verbal memory scores (p for all < 0.05). There was a significant interaction in the magnitude of this association with race (p < 0.01), such that the association of verbal memory scores with endothelial progenitor subsets was present in Black but not in non-Black participants. No associations were present with the hematopoietic progenitor-enriched cells or with the Trail Making Tests. Lower numbers of circulating endothelial progenitor cells are associated with cognitive impairment in patients with CAD, suggesting a protective effect of repair/regeneration processes in the maintenance of cognitive status. Impairment of verbal memory function was more strongly associated with lower CPC counts in Black compared to non-Black participants with CAD. Whether strategies designed to improve regenerative capacity will improve cognition needs further study.