Chemical-induced DNA damage and human cancer risk
Chemical-induced DNA damage and human cancer risk
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DOI：
10.1038/nrc1441
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发表时间：
2004-09
影响因子：
78.5
通讯作者：
M. Poirier
中科院分区：
文献类型：
--
作者：
M. Poirier
化学致癌涉及一系列复杂的事件，其中最早的通常包括DNA损伤和DNA突变的固定。已经开发出复杂的新技术来量化DNA损伤并将损伤量与癌症风险相关联。中国林县正在采取这样的方法，那里的食物含有高水平的破坏DNA的致癌多环芳烃（PAH），食管癌的死亡率很高。更好地了解多环芳烃暴露可能增加食道癌风险的机制可能会带来新的癌症预防策略。
Chemical carcinogenesis involves a complex series of events, the earliest of which typically include DNA damage and the fixation of DNA mutations. Sophisticated new techniques have been developed to quantify DNA damage and to correlate the amount of damage with cancer risk. Approaches such as these are underway in Linxian, China, where food contains high levels of DNA-damaging, carcinogenic polycyclic aromatic hydrocarbons (PAHs), and where there is high mortality from oesophageal cancer. Gaining better insight into the mechanisms by which PAH exposure might increase oesophageal cancer risk could lead to new strategies for cancer prevention.