Limbic Pathway Correlates of Cognitive Impairment in Multiple Sclerosis.
Limbic Pathway Correlates of Cognitive Impairment in Multiple Sclerosis.
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DOI：
10.1111/jon.12381
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发表时间：
2017-01
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影响因子：
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通讯作者：
Nelson FM
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文献类型：
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作者：
Keser Z;Hasan KM;Mwangi B;Gabr RE;Steinberg JL;Wilken J;Wolinsky JS;Nelson FM
多种边缘白色物质通路的不同损伤已被报道与多发性硬化症（MS）认知功能障碍的不同方面相关。扩散张量成像（DTI）提供了一种非侵入性的方法来映射组织的微观结构组织。我们利用定量磁共振成像的方法来分析主要边缘系统白质结构的MS患者的认知功能障碍（CI）。对10例认知功能无损害的MS（MSNI）患者和36例诊断为CI（MSCI）的MS患者进行了最小认知功能评估（MACFIMS）。穹隆、扣带、钩束（UF）的DTI测量包括束体积和相应的各向异性分数（FA）、平均（MD）、轴向（AD）和径向（AD）扩散率。在调整混杂因素后，对这些与CI的相关性进行统计学分析。MSNI与MSCT的穹窿FA和RD，左侧扣带FA、MD和RD，右侧扣带FA、MD和RD，以及左侧UF FA显示了显著差异（P < .001）。在回归分析中，穹窿FA（r =-0.6）和RD（r = 0.52）以及右侧扣带FA（r =-0.54）和RD（r = 0.5）与CI显著相关。使用DTI对主要边缘系统通路中微观结构紊乱的破坏程度影响了MS受试者中观察到的CI程度。
Distinct injuries to various limbic white matter pathways have been reported to be associated with different aspects of cognitive dysfunction in multiple sclerosis (MS). Diffusion tensor imaging (DTI) offers a noninvasive method to map tissue microstructural organization. We utilized quantitative magnetic resonance imaging methods to analyze the main limbic system—white matter structures in MS patients with cognitive impairment (CI). Ten cognitively nonimpaired MS (MSNI) patients and 36 patients with diagnosed CI (MSCI) underwent the minimal assessment of Cognitive Function in MS (MACFIMS) battery. DTI measures of fornix, cingulum, uncinate fasciculus (UF) included tract volume and corresponding fractional anisotropy (FA), mean (MD), axial (AD), and radial (AD) diffusivities. These were statistically analyzed for associations with CI after adjusting for the confounders. Fornix FA and RD, left cingulum FA, MD, and RD, right cingulum FA, MD, and RD, and left UF FA showed significant differences between MSNI and MSCI (P < .001). Fornix FA (r = −.6) and RD (r = .52), and right cingulum FA (r = −.54) and RD (r = .5) correlated significantly with CI in regression analyses. The extent of disruption of microstructural disorganization in the main limbic pathways using DTI impacts the extent of CI seen in subjects with MS.