Old lysosomes, new tricks: MHC II dynamics in DCs
Old lysosomes, new tricks: MHC II dynamics in DCs
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DOI：
10.1016/j.it.2004.11.008
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发表时间：
2005-02-01
影响因子：
16.8
通讯作者：
Mellman, I
中科院分区：
文献类型：
--
作者：
Chow, AY;Mellman, I
MHC II-restricted antigen presentation typically results in recognition of exogenous foreign peptides by T lymphocytes and the subsequent generation of a cellular immune response. It is well known that the intracellular events involved in the assembly of peptideMHC 11 complexes occur in the endocytic pathway. However, a point not often considered by immunologists is that the nature of these events suggests contradictions between the fundamental characteristics of the endocytic pathway as defined in non-specialized cells and those features necessary to facilitate efficient IMIHC If antigen processing in antigen-presenting cells. We believe that one reason why dendritic cells are so efficient at T-cell stimulation is their ability to reconcile these contradictions by regulating the activities and dynamics of their otherwise 'normal' complement of endocytic organelles.
