The effect of acute citalopram on face emotion processing in remitted depression: A pharmacoMRI study
The effect of acute citalopram on face emotion processing in remitted depression: A pharmacoMRI study
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DOI：
10.1016/j.euroneuro.2010.06.008
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发表时间：
2011-01-01
影响因子：
5.6
通讯作者：
Elliott, Rebecca
中科院分区：
文献类型：
--
作者：
Anderson, Ian M.;Juhasz, Gabriella;Elliott, Rebecca
多巴胺能（5-HT）功能的降低和消极的情绪偏见都与抑郁症的易感性有关。为了调查这些是否可能相关，我们研究了5-HT调制的情感处理在14个缓解抑郁症患者与12个从未抑郁症的年龄和性别相匹配的控制。参与者进行功能磁共振成像（fMRI）在一个隐蔽的面部情绪任务与和没有静脉注射西酞普兰（7.5毫克）预处理。与观察中性面孔相比，无论哪一组，西酞普兰增强了左前扣带回血氧水平依赖性（BOLD）反应快乐的面孔，右后扣带回和右侧眶额反应悲伤的面孔，并减少杏仁核反应双边恐惧的面孔。在对照组中，相对于缓解的抑郁症受试者，西酞普兰增加了双侧海马对快乐面孔的反应，增加了右前额叶对悲伤面孔的反应。这些发现并没有被解释为观看中性面孔时BOLD反应的变化。这些结果是一致的，与以前的研究结果显示5-HT调制的情感处理，与对照组相比，在以前抑郁的参与者中发现的差异可能有助于情绪处理偏见潜在的脆弱性抑郁症复发。(C)2010 Elsevier B.V.和ECNP。All rights reserved.
Both reduced serotonergic (5-HT) function and negative emotional biases have been associated with vulnerability to depression. In order to investigate whether these might be related we examined 5-HT modulation of affective processing in 14 remitted depressed subjects compared with 12 never depressed controls matched for age and sex. Participants underwent function magnetic resonance imaging (fMRI) during a covert face emotion task with and without intravenous citalopram (7.5 mg) pretreatment. Compared with viewing neutral faces, and irrespective of group, citalopram enhanced left anterior cingulate blood oxygen level dependent (BOLD) response to happy faces, right posterior insula and right lateral orbitofrontal responses to sad faces, and reduced amygdala responses bilaterally to fearful faces. In controls, relative to remitted depressed subjects, citalopram increased bilateral hippocampal responses to happy faces and increased right anterior insula response to sad faces. These findings were not accounted for by changes in BOLD responses to viewing neutral faces. These results are consistent with previous findings showing 5-HT modulation of affective processing; differences found in previously depressed participants compared with controls may contribute to emotional processing biases underlying vulnerability to depressive relapse. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.