Body size and the risk of colon cancer in a large case-control study
Body size and the risk of colon cancer in a large case-control study
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DOI：
10.1038/sj.ijo.0800561
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发表时间：
1998-02-01
影响因子：
4.9
通讯作者：
Edwards, SM
中科院分区：
文献类型：
--
作者：
Caan, BJ;Coates, AO;Edwards, SM
目的：探讨身高、体重、体脂分布与结肠癌在性别、年龄、结肠部位亚类中的相关性，以及与结直肠癌家族史的相互作用。设计：饮食、人体测量和结肠癌风险的病例对照研究。研究对象：1983例结肠癌病例（30-79岁）和2400例年龄和性别匹配的人群对照。测量方法：由训练有素的采访者获得身高、体重和腰臀围，计算身体质量指数（BMI）和腰臀比（WHR）。结果：在所有被检查的人体测量中，只有BMI与结肠癌风险增加一致相关。BMI趋势的测试对男性和女性整体以及大多数被检查的亚组都很重要。在年轻人中，有结直肠癌家族史的人患结肠癌的风险与BMI相关(男性优势比(OR) = 7.76, 95%可信区间（CI） 2.60, 23.1；女性OR = 4.85, 95% CI 2.33, 10.12)，与没有家族史的患者相比（男性OR = 1.70 95% CI 1.25, 2.32；女性OR = 1.53 95% CI 1.22, 1.92）。在控制BMI后，WHR与男性结肠癌无关，而与女性（主要是远端肿瘤患者）的轻微增加有关。结论：这项研究为超重与结肠癌风险增加有关提供了越来越多的证据。
OBJECTIVE: To investigate the risks of height, weight and body fat distribution associated with colon cancer in subcategories of gender, age and site in the colon, Interaction with family history of colorectal cancer is also examined.DESIGN: Case-control study of diet, anthropometry and colon cancer risk.SUBJECTS: Nineteen hundred and eighty-three colon cancer cases (age 30-79 y) and 2400 age and gender matched population controls.MEASUREMENTS: Height, weight and waist and hip circumferences were obtained by trained interviewers, Body Mass Index (BMI) and Waist-Hip Ratio (WHR) were calculated.RESULTS: Of all anthropometric measurements examined, only BMI was consistently associated with an increased risk our colon cancer. The test for trend for BMI was significant for men and women overall and for the majority of subgroups examined. in younger persons those with a family history of colorectal cancer had a greater risk of colon cancer associated with BMI (Man odds ratio (OR) = 7.76, 95% confidence interval (CI) 2.60, 23.1; Women OR = 4.85, 95% CI 2.33, 10.12) comparing the third tertile to the first, than those with no family history (Men OR = 1.70 95% CI 1.25, 2.32; Women OR = 1.53 95% CI 1.22, 1.92). WHR, after controlling for BMI was not associated with colon cancer in men, and was associated with a slight increase in women (primarily in those with distal tumors).CONCLUSION: This study contributes to mounting evidence that excess weight is associated with an increased risk of colon cancer.