Intravenous cyclosporine in attacks of ulcerative colitis - Short-term and long-term responses
Intravenous cyclosporine in attacks of ulcerative colitis - Short-term and long-term responses
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DOI：
10.1007/bf02100145
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发表时间：
1996-12-01
影响因子：
3.1
通讯作者：
Gendre, JP
中科院分区：
文献类型：
--
作者：
Carbonnel, F;Boruchowicz, A;Gendre, JP
本研究报告了32例难治性和/或重度溃疡性结肠炎（UC）患者静脉注射环孢素的结果。32例患者中有20例对静脉注射环孢素有反应；环孢素临床有效，改善结肠病变。然而，在两例使用大剂量皮质类固醇和环孢素未能达到临床缓解的严重内镜下结肠炎患者中，观察到一例结肠穿孔和一例术后死亡。此外，在中位随访190天后，只有三分之一的患者避免了结肠切除术。未发现对环孢素反应的预测因素。本研究证实环孢素对严重UC有效，但对皮质类固醇和环孢素治疗失败的严重病变患者，环孢素的使用可能与严重并发症有关。
The present study reports the results of intravenous cyclosporine in 32 patients with refractory and/or severe attacks of ulcerative colitis (UC). Twenty of 32 patients responded to intravenous cyclosporine; cyclosporine was clinically effective and improved colonic lesions. However, one colonic perforation and one postoperative death were observed in two patients with severe endoscopic colitis who had failed to reach clinical remission with high-dose corticosteroids and cyclosporine. Moreover, after a median follow-up of 190 days, only one-third of the patients avoided colectomy. No predictive factor of response to cyclosporine was identified. This study confirms that cyclosporine is effective in severe UC but suggests that its use could be associated with serious complications in patients with severe lesions who had failed to settle with corticosteroids and cyclosporine.