All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies
All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies
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DOI：
10.1097/00007890-200210270-00025
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发表时间：
2002-10-27
期刊：
影响因子：
6.2
通讯作者：
Lei, HY
中科院分区：
文献类型：
--
作者：
Lee, PC;Terasaki, PI;Lei, HY
背景最近的研究表明，几乎所有肾移植排斥的患者都有人类白细胞抗原（HIA）抗体。在这项研究中，我们试图确定患者是否在慢性排斥反应前产生HIA抗体。在过去的8年中，139例接受肾移植的患者进行了系统的检查，使用酶联免疫吸附试验为基础的方法，为发展的I类和II类HLA抗体移植后3个月，6个月，每年。活检诊断为慢性排斥反应。在29例慢性排斥反应患者中，100%的患者在排斥反应前就有HLA抗体。在这些患者中，14例患者产生了新生抗体。相反，在110例功能稳定的患者中，27%的患者在移植后产生了HLA抗体（P
Background. Recent studies show that almost all patients who have rejected a kidney transplant had human leukocyte antigen (HIA) antibodies. In this study, we sought to determine whether patients develop HIA antibodies before chronic rejection.Methods. For the past 8 years, 139 patients who had undergone kidney transplantation were systematically examined, using an enzyme-linked immunosorbent assay-based method, for the development of class-I and class-II HLA antibodies 3 months, 6 months, and yearly after transplantation. Chronic rejection was diagnosed by biopsy.Results. Among 29 patients with chronic rejection, 100% of the patients had HLA antibodies before rejection. Of these patients, 14 patients developed antibodies de novo. In contrast, among 110 patients with stable function, 27% of the patients developed HLA antibodies posttransplant (P