Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.
Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.
复制标题
病毒 DNA 聚合酶基因中含有耐药突变的单纯疱疹病毒突变体的致病性。
DOI：
10.1128/jvi.60.1.286-289.1986
复制
发表时间：
1986
影响因子：
5.4
通讯作者：
Coen,DM
中科院分区：
文献类型：
--
作者：
Field,HJ;Coen,DM
三个单纯疱疹病毒突变体，含有耐药突变的DNA聚合酶基因表现出没有显着减少在小鼠的耳朵中的复制与野生型相比，在该网站接种后，但脑内接种后的致病性减弱。白内障是突变感染后存活的小鼠常见的后遗症。
Three herpes simplex virus mutants that contain drug resistance mutations in the DNA polymerase gene exhibited no significant reduction in replication in the ears of mice compared with the wild type after inoculation at that site but were attenuated for pathogenicity after intracerebral inoculation. Cataracts were common sequelae in mice that survived mutant infections.