Ultraviolet light-induced suppression of antigen presentation.
Ultraviolet light-induced suppression of antigen presentation.
复制标题
紫外线诱导的抗原呈递抑制。
DOI：
10.1007/bf00915480
复制
发表时间：
1983
影响因子：
9.1
通讯作者：
Tomasi,TB
中科院分区：
文献类型：
--
作者：
Spellman,CW;Tomasi,TB
紫外线(UV)照射动物可产生特异性T抑制细胞，抑制抗肿瘤免疫反应。据认为，这种抑制可能是紫外线照射的表皮细胞抗原提呈改变的结果。这一假说是基于证据表明，紫外线照射的宿主的特定淋巴组织表现出抗原提呈功能受损，并且当抗原被施加到紫外线照射的皮肤部位时，动物不能被接触性致敏。皮肤朗格汉斯细胞可能是紫外线诱导的抗原提呈缺陷的靶点，因为它们携带Fc和C3b受体，表达Ia抗原，来自骨髓，并能够在体外提呈抗原。我们推测紫外线诱导的对特定抗原的耐受可能在临床上有用，例如在单抗治疗和组织移植中遇到的那些。
Ultraviolet (UV) light irradiation of animals results in the development of specific T suppressor cells that inhibit antitumor immune responses. It is thought that suppression may arise as a consequence of altered antigen presentation by UV-irradiated epidermal cells. This hypothesis is based on evidence demonstrating that specific lymphoid tissues from UV-irradiated hosts exhibit impaired antigen-presenting function and that animals cannot be contact sensitized when antigens are applied to a UV-irradiated skin site. Langerhans cells of the skin are likely candidates as targets of UV-induced defects in antigen presentation as they bear Fc and C3b receptors, express Ia antigens, are of bone marrow origin, and are capable of presenting antigenin vitro. We speculate on the possible clinical usefulness of UV-induced tolerance to specific antigens such as those encountered in monoclonal antibody therapy and tissue transplantation.