Nickel-Mediated Synthesis of Isoindolinones at Room Temperature.
Nickel-Mediated Synthesis of Isoindolinones at Room Temperature.
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室温下镍介导的异吲哚啉酮合成。
DOI：
10.1055/s-0034-1378555
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kalyani,Dipannita
中科院分区：
文献类型：
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作者：
Wertjes,WilliamC;Waller,PeterJ;Shelton,KyleE;Kalyani,Dipannita
该通信描述了一种用于Ni（cod）2介导的苯甲酰胺底物中与氮原子相邻的烷基C-H键的分子内芳基化的方法。该转化在室温下进行，并对更多取代的C-H键的官能化表现出选择性。所需异吲哚啉酮产物的产率在氮原子上含有叔烷基的苯甲酰胺底物中高于那些带有伯或仲烷基的苯甲酰胺底物。本文所述的结果表明，涉及这些反应的自由基中间体的机制。
This communication describes a method for the Ni(cod)2-mediated intramolecular arylation of alkyl C−H bonds adjacent to the nitrogen atom in benzamide substrates. The transformation proceeds at room temperature and exhibits selectivity for functionalization of more substituted C−H bonds. The yields of the desired isoindolinone products are higher with benzamide substrates containing tertiary alkyl groups on the nitrogen atom than with those bearing primary or secondary alkyls. The results described herein suggest a mechanism involving radical intermediates for these reactions.