Structural insights into NMDA receptor pharmacology.
Structural insights into NMDA receptor pharmacology.
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DOI：
10.1042/bst20230122
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发表时间：
2023-08-31
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
N-甲基-d-天冬氨酸受体（NMDAR）包括离子型谷氨酸受体的亚家族，其形成异四聚体配体门控离子通道，并且在神经元过程如突触信号传导和可塑性中发挥基本作用。鉴于它们在脑功能中的关键作用和它们的治疗重要性，大量的研究工作已经致力于阐明这些受体的结构和功能并开发新的治疗方法。最近的研究已经解决了多个功能状态的NMDAR的结构，并揭示了详细的门控机制，这被发现是不同于其他离子型谷氨酸受体。本文综述了近年来NMDARs结构及其功能机制的研究进展，重点介绍了亚型特异性配体诱导的构象动力学。
N-methyl-d-aspartate receptors (NMDARs) comprise a subfamily of ionotropic glutamate receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles in neuronal processes such as synaptic signaling and plasticity. Given their critical roles in brain function and their therapeutic importance, enormous research efforts have been devoted to elucidating the structure and function of these receptors and developing novel therapeutics. Recent studies have resolved the structures of NMDARs in multiple functional states, and have revealed the detailed gating mechanism, which was found to be distinct from that of other ionotropic glutamate receptors. This review provides a brief overview of the recent progress in understanding the structures of NMDARs and the mechanisms underlying their function, focusing on subtype-specific, ligand-induced conformational dynamics.
影响因子：
3.7
作者：
Lee CH;Gouaux E
通讯作者：
Gouaux E
NMDA受体激活需要在配体结合异二聚体内重塑亚基间接触。
影响因子：
16.6
作者：
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