Deformylase as a novel antibacterial target.
Deformylase as a novel antibacterial target.
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DOI：
10.1016/s1359-6446(01)01925-0
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发表时间：
2001-09
影响因子：
7.4
通讯作者：
Zhengyu Yuan;J. Trias;Richard J. White
中科院分区：
文献类型：
--
作者：
Zhengyu Yuan;J. Trias;Richard J. White
细菌基因组学已经揭示了大量以前未知的潜在用途的目标，在发现新的抗菌药物。然而，到目前为止，这一办法收效甚微。肽脱甲酰基酶是30多年前发现的一个有趣的靶点，但直到最近才被利用。对该靶标的兴趣重新唤醒源于对该酶的更好理解，使其成为更易处理和更有吸引力的靶标。信息的酶的特性，如其三维结构，抑制剂的活性，其阻力和适合作为目标进行了讨论。
Bacterial genomics has revealed a plethora of previously unknown targets of potential use in the discovery of novel antibacterial drugs. However, so far little has emerged from this approach. Peptide deformylase is an interesting target that was discovered more than 30 years ago, but was not exploited until recently. The reawakening of interest in this target resulted from an improved understanding of the enzyme, making it a more tractable and attractive target. Information on the properties of the enzyme, such as its three-dimensional structure, the activity of inhibitors, its resistance and suitability as a target are discussed.