FETAL TRACHEAL LIGATION AND LUNG DEVELOPMENT
FETAL TRACHEAL LIGATION AND LUNG DEVELOPMENT
复制标题
DOI：
10.1001/archpedi.1965.02090020454014
复制
发表时间：
1965-01-01
影响因子：
--
通讯作者：
ADAMS, FH
中科院分区：
文献类型：
--
作者：
CARMEL, JA;FRIEDMAN, F;ADAMS, FH
对近足月妊娠家兔进行手术，其中一半胎儿的气管被结扎以防止吸入羊水，另一半进行假手术。允许胎仔在子宫内停留不同时间，最长5天。然后，她们通过剖腹产分娩，在对照组可以呼吸之前，头部被绑住。将肺游离解剖，测量肺重量和体积，并制备组织学标本。与假手术对照组相比，在实验肺中观察到肺重量和体积的显著增加。显微镜检查显示肺泡发育正常，但在实验肺中，也有证据表明肺泡和终末细支气管扩张以及壁变薄。可以合理地得出结论，肺中产生液体以抵抗静水压力，并且在没有羊水吸入的情况下发生正常的肺发育。
Operations were done on near-term pregnant rabbits in which the tracheas of half the fetuses were ligated to prevent aspiration of amniotic fluid and sham operations performed on the other half. The fetuses were allowed to remain in utero for varying periods up to 5 days. They were then delivered by cesarean section and the heads tied off before a single breath could be taken by the controls. The lungs were dissected free, lung weights and volumes measured, and histological preparations made. Significant increase of both lung weight and volume was observed in the experimental lungs as compared to those of the sham operated controls. Microscopic examination showed normal alveolar development, but in the experimental lungs there was also evidence of dilatation of alveoli and terminal bronchioles as well as thinning of their walls. It is logical to conclude that a fluid is produced in the lung against a hydrostatic pressure and that normal lung development occurs in the absence of amniotic fluid aspirations.