Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata.
Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata.
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伴有自身免疫性甲状腺疾病和斑秃的非节段性白癜风中循环 CXCL10 增加
DOI：
10.5021/ad.2019.31.4.393
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发表时间：
2019-08
影响因子：
1.6
通讯作者：
Xiang L
中科院分区：
文献类型：
--
作者：
Zhang L;Xu X;Chen S;Kang Y;Wang X;Zhang C;Xiang L
背景白癜风是一种常见的获得性色素性皮肤病，是由于自身免疫反应引起表皮黑素细胞破坏所致。趋化因子在伴有自身免疫性甲状腺疾病（AITD）和斑秃（AA）的非节段性白癜风（NSV）中的作用研究较少。目的本研究的目的是确定预测白癜风进展的最佳血清生物标志物，并通过使用生物标志物评估AA和/或AITD对白癜风的影响。方法采用前瞻性队列研究方法，收集45例NSV患者，其中14例无AITD或AA，12例AITD，11例AA，8例AITD和AA。通过ELISA分析CXCL 1、CXCL 8、CXCL 9、CXCL 10、CXCL 12、CXCL 13和CXCL 16的血清水平。RT-PCR检测PBMC上CXCR 3 mRNA的表达。使用色素沉着量表评价改善情况。结果NSV合并AITD或AA患者血清CXCL 10水平及CXCR 3 mRNA表达沿着增高，而NSV合并AITD或AA患者血清CXCL 10水平及CXCR 3 mRNA表达均高于无AITD或AA患者。此外，血清CXCL 10水平，沿着CXCR 3 mRNA的表达在NSV合并AITD和AA患者中高于AITD或AA单独患者。NSV合并AA和AITD患者的色素沉着比单纯AA或AITD患者更明显。结论CXCL 10可作为预测NSV进展的生物标志物。皮肤科医生应高度重视NSV合并AITD和/或AA的患者，因为合并症可能导致更活跃的自身免疫反应。
Background Vitiligo is a common acquired pigmentary disease caused by destruction of epidermal melanocytes in underlying autoimmune response. Few studies have been focused on the role of chemokines in non-segmental vitiligo (NSV) concomitant with autoimmune thyroid disease (AITD) and alopecia areata (AA). Objective The aim of this study was to determine the best serum biomarker for predictive role in the progression of vitiligo and to evaluate the influence of AA and/or AITD on vitiligo by using the biomarker. Methods This prospective cohort study recruited 45 NSV patients: 14 without either AITD or AA, 12 with AITD, 11 with AA, and 8 with both AITD and AA. Serum levels of CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13, and CXCL16 were analyzed by ELISA. CXCR3 mRNA expression was detected on PBMCs by RT-PCR. Improvement was evaluated using repigmentation scales. Results Serum CXCL10 levels, along with the expression of CXCR3 mRNA were higher in NSV patients with AITD or AA alone than in those without AITD or AA. Moreover, serum CXCL10 levels, along with the expression of CXCR3 mRNA were higher in NSV patients with both AITD and AA than in those with AITD or AA alone. Poorer repigmentation was observed in NSV patients with both AA and AITD than in those with AA or AITD alone. Conclusion CXCL10 could be a biomarker to predict the progression of NSV. Dermatologists should pay much attention to those NSV patients concomitant with AITD and/or AA, for comorbidity might lead to more active autoimmune reaction.
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影响因子：
3.6
作者：
Rork JF;Rashighi M;Harris JE
通讯作者：
Harris JE
DOI：
10.1111/j.1600-0749.2005.00242.x
发表时间：
2005-08-01
期刊：
PIGMENT CELL RESEARCH
影响因子：
--
作者：
Laberge, G;Mailloux, CM;Spritz, RA
通讯作者：
Spritz, RA
影响因子：
4.5
作者：
Medici M;Porcu E;Pistis G;Teumer A;Brown SJ;Jensen RA;Rawal R;Roef GL;Plantinga TS;Vermeulen SH;Lahti J;Simmonds MJ;Husemoen LL;Freathy RM;Shields BM;Pietzner D;Nagy R;Broer L;Chaker L;Korevaar TI;Plia MG;Sala C;Völker U;Richards JB;Sweep FC;Gieger C;Corre T;Kajantie E;Thuesen B;Taes YE;Visser WE;Hattersley AT;Kratzsch J;Hamilton A;Li W;Homuth G;Lobina M;Mariotti S;Soranzo N;Cocca M;Nauck M;Spielhagen C;Ross A;Arnold A;van de Bunt M;Liyanarachchi S;Heier M;Grabe HJ;Masciullo C;Galesloot TE;Lim EM;Reischl E;Leedman PJ;Lai S;Delitala A;Bremner AP;Philips DI;Beilby JP;Mulas A;Vocale M;Abecasis G;Forsen T;James A;Widen E;Hui J;Prokisch H;Rietzschel EE;Palotie A;Feddema P;Fletcher SJ;Schramm K;Rotter JI;Kluttig A;Radke D;Traglia M;Surdulescu GL;He H;Franklyn JA;Tiller D;Vaidya B;de Meyer T;Jørgensen T;Eriksson JG;O'Leary PC;Wichmann E;Hermus AR;Psaty BM;Ittermann T;Hofman A;Bosi E;Schlessinger D;Wallaschofski H;Pirastu N;Aulchenko YS;de la Chapelle A;Netea-Maier RT;Gough SC;Meyer Zu Schwabedissen H;Frayling TM;Kaufman JM;Linneberg A;Räikkönen K;Smit JW;Kiemeney LA;Rivadeneira F;Uitterlinden AG;Walsh JP;Meisinger C;den Heijer M;Visser TJ;Spector TD;Wilson SG;Völzke H;Cappola A;Toniolo D;Sanna S;Naitza S;Peeters RP
通讯作者：
Peeters RP
影响因子：
8.7
作者：
Harris JE
通讯作者：
Harris JE
影响因子：
6.6
作者：
Nanba, Takashi;Watanabe, Mikio;Iwatani, Yoshinori
通讯作者：
Iwatani, Yoshinori