A mapping review of refinements to laboratory rat housing and husbandry.
A mapping review of refinements to laboratory rat housing and husbandry.
复制标题
对实验室大鼠饲养和饲养改进的绘图审查。
DOI：
10.1038/s41684-023-01124-1
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发表时间：
2023
期刊：
影响因子：
6.9
通讯作者：
Neville V
中科院分区：
文献类型：
--
作者：
Neville V
改进实验室大鼠的饲养和饲养是一个重要的目标，这既是出于伦理原因，也是为了提高研究质量。我们对1017项研究进行了制图回顾，这些研究调查了实验室大鼠的住房和饲养的潜在改进，以评估哪些改进已被研究，哪些尚未被研究，并简要评估是否有证据支持对大鼠福利的任何影响。在研究的许多改进中，大多数涉及改变笼子，但有些也涉及改变更广泛的环境。这些改进的效果是用一系列读数来评估的，其中许多读数很难从福利的角度来解释。偏好研究更容易解释，它提供的证据表明，老鼠更喜欢复杂的环境，包括庇护所和多种物体，这些环境提供了不同的区域/资源，允许老鼠从事不同的行为。论文中对方法的报道往往很差，这表明研究可能存在偏见。考虑到许多改进同时发生，通常很难区分哪些对老鼠的福利最有益。改善的效果也受到许多因素的影响，包括年龄、性别、压力和光周期。总的来说，我们的研究结果表明，一种适合所有人的改良方法是不合适的，因为不同的改良会以不同的方式影响不同的老鼠。我们的审查还产生了一个包含100 000篇文章的数据库，可用于进一步和更详细的分析。我们的发现也强调了未来研究可能有价值的领域，包括改进老鼠的运输、处理和训练的使用。
Refining the housing and husbandry of laboratory rats is an important goal, both for ethical reasons and to allow better quality research. We conducted a mapping review of 1,017 studies investigating potential refinements of housing and husbandry of the laboratory rat to assess what refinements have, and have not, been studied, and to briefly assess whether there is evidence to support any impact on rat welfare. Among the many refinements studied, the majority involve changes to the cage, but some also involve alterations to the wider environment. The effects of these refinements were assessed using a range of readouts, many of which are difficult to interpret from a welfare perspective. Preference studies, which are easier to interpret, provide evidence that rats prefer complex environments, including shelters and multiple objects, which offer different areas/resources allowing the rat to engage in diverse behaviors. The reporting of methodology in papers was often poor, indicating that studies were potentially subject to biases. Given that many refinements co-occurred, it was often difficult to tease apart which ones were most beneficial for rat welfare. Effects of refinements were also moderated by a number of factors including age, sex, strain and photoperiod. Altogether our findings show that a one-size-fits-all approach to refinements is not appropriate, because different refinements will impact different rats in different ways. Our review has also produced a database of >1,000 articles that can be used for further and more detailed analyses. Our findings have also highlighted areas where future research is likely to be valuable, including refinements to rat transport, handling and the use of training.