Reserpine‐induced sulphomucin production by goblet cells in the jejunum of rats and its significance in the establishment of intestinal helminths
Reserpine‐induced sulphomucin production by goblet cells in the jejunum of rats and its significance in the establishment of intestinal helminths
复制标题
利血平诱导大鼠空肠杯状细胞产生硫粘蛋白及其在肠道蠕虫形成中的意义
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Y. Nawa
中科院分区：
文献类型：
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作者：
N. Ishikawa;B. Shi;A. I. Khan;Y. Nawa
本研究旨在确定利血平诱导的大鼠小肠杯状细胞粘蛋白硫酸化增加是否影响肠道蠕虫的建立。当Wistar大鼠每天腹腔注射利血平，持续7天，然后将500只委内瑞拉圆线虫蠕虫植入尿道内时，利血平处理大鼠肠道中建立的蠕虫数量约为对照组的一半。此外，当肥大细胞缺陷的Ws/Ws大鼠用利血平处理并同时植入S.委内瑞拉线虫和巴西日本圆线虫蠕虫的建立，前者，而不是后者，显着抑制。这些结果表明，由小肠杯状细胞产生和分泌的粘蛋白的理化性质可能是建立特定种类的肠道蠕虫的关键。
The present investigation was undertaken to determine whether reserpine‐induced increase in the sulphation of the small intestinal goblet cell mucins of rats affects the establishment of intestinal helminths. When Wistar rats were given daily intraperitoneal injections of reserpine for seven days and were then implanted intraduodenally with 500 Strongyloides venezuelensis adult worms, the number of adult worms established in the intestine of reserpine‐treated rats was about half of that established in controls. Furthermore, when mast cell‐deficient Ws/Ws rats were treated with reserpine and implanted concurrently with S. venezuelensis and Nippostrongylus brasiliensis adult worms, the establishment of the former, but not the latter, was significantly suppressed. These results imply that the physicochemical properties of the mucins produced and secreted by the small intestinal goblet cells may be critical for the establishment of particular species of intestinal helminths.