A Randomized Double Blinded Placebo-Controlled Clinical Trial of a Probiotic or Metronidazole for Acute Canine Diarrhea
A Randomized Double Blinded Placebo-Controlled Clinical Trial of a Probiotic or Metronidazole for Acute Canine Diarrhea
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DOI：
10.3389/fvets.2019.00163
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发表时间：
2019-06-04
影响因子：
3.2
通讯作者：
Buckley, Gareth J.
中科院分区：
文献类型：
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作者：
Shmalberg, Justin;Montalbano, Christina;Buckley, Gareth J.
急性腹泻是一种常见的，往往是自限性的，原因介绍兽医护理，但有一个经常处方治疗的数据缺乏。这项随机双盲安慰剂对照临床试验的目的是比较两种轶事推荐的治疗方法：益生菌组合和甲硝唑。将60只无并发症的犬随机分为3个治疗组。使用主人调查和粪便评分表评价至腹泻体征消退的时间。出现急性腹泻的犬在接受益生菌治疗后3.5 +/- 2.2天、口服甲硝唑治疗后4.6 +/- 2.4天和安慰剂治疗后4.8 +/- 2.9天达到可接受的粪便稠度;治疗组之间未发现统计学显著差异（p = 0.17）。这些发现未能为甲硝唑在急性犬腹泻犬队列中的普遍使用提供证据，并且需要更大的研究人群来确定益生菌的统计学显著效果。
Acute diarrhea is a common, often self-limiting, cause of presentation for veterinary care, yet there is a paucity of data on frequently-prescribed treatments. The purpose of this randomized, double blinded placebo-controlled clinical trial was to compare two anecdotally-recommended treatments: a probiotic combination and metronidazole. Sixty dogs without concurrent comorbidities were randomized into three treatment groups. The time to resolution of diarrheal signs was evaluated using owner surveys and fecal scoring charts. Dogs presenting with acute diarrhea achieved acceptable fecal consistency after 3.5 +/- 2.2 days when receiving probiotic, 4.6 +/- 2.4 days with oral metronidazole, and 4.8 +/- 2.9 days with placebo; statistically significant differences were not identified between treatment groups (p = 0.17). These findings failed to provide evidence for the common use of metronidazole in this cohort of dogs with acute canine diarrhea, and a larger study population would be required to identify a statistically significant effect of probiotics.