Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism
Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism
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DOI：
10.1176/ajp.157.1.75
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发表时间：
2000-01-01
影响因子：
17.7
通讯作者：
Pappas, N
中科院分区：
文献类型：
--
作者：
Volkow, ND;Logan, J;Pappas, N
目的：尽管有充分的证据证明大脑多巴胺活性随着年龄的增长而丧失，但对健康个体的功能后果知之甚少。这项研究调查了健康个体脑多巴胺D-2受体（传递多巴胺信号的分子）和局部脑葡萄糖代谢（脑功能的标志物）之间的关系。方法：37名24-86岁的健康志愿者在注射[C-11]雷氯必利后接受正电子发射断层扫描，以评估多巴胺D-2受体和[（18）]氟脱氧葡萄糖，以评估局部脑葡萄糖代谢。两种方法用于评估代谢和多巴胺D-2受体之间的相关性像素像素的相关性和相关性在预选区域的利益，然后进行了比较。结果：D-2受体以及额叶和扣带回代谢随年龄增长而下降。无论使用何种方法，在额叶皮层（布罗德曼区域6、7、8、9、10、11、44、45、47）、前扣带回（区域24、32）、颞叶皮层（区域21）和尾状核中发现代谢和D-2受体之间的显著相关性。这些相关性在去除年龄效应后仍然显著（偏相关）。结论：这些结果提供了与年龄相关的脑多巴胺活性下降与额叶和扣带回代谢之间的第一个联系，这支持了研究增强老年人多巴胺功能的干预措施的治疗效用的必要性。事实上，相关性仍然显着删除年龄的影响后，表明多巴胺可能会影响额叶，扣带回和颞叶代谢，无论年龄。
Objective: Despite the well-documented loss of brain dopamine activity with age, little is known about its functional consequences in healthy individuals. This study investigates the relationship between measures of brain dopamine D-2 receptors (molecules that transmit dopamine signals) and regional brain glucose metabolism (a marker of brain function) in healthy individuals. Method: Thirty-seven healthy volunteers aged 24-86 years underwent positron emission tomography scans after injection of [C-11]raclopride to assess dopamine D-2 receptors and [(18)]fluorodeoxyglucose to assess regional brain glucose metabolism. Two methods used to assess the correlations between metabolism and dopamine D-2 receptors-pixel-by-pixel correlations and correlations in preselected regions of interest-were then compared. Results: D-2 receptors as well as frontal and cingulate metabolism declined with age. Regardless of the method used, significant correlations between metabolism and D-2 receptors were found in the frontal cortex (Brodmann's areas 6, 7, 8, 9, 10, 11, 44, 45, 47), anterior cingulate gyrus (areas 24, 32), temporal cortex (area 21), and caudate. These correlations remained significant after removing age effects (partial correlation). Conclusions: These results provide the first link between age-related declines in brain dopamine activity and frontal and cingulate metabolism, which supports the need to investigate the therapeutic utility of interventions that enhance dopamine function in the elderly. The fact that correlations remained significant after removing age effects suggests that dopamine may influence frontal, cingulate, and temporal metabolism regardless of age.