Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population
Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population
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DOI：
10.1016/j.diabres.2009.03.002
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发表时间：
2009-06-01
影响因子：
5.1
通讯作者：
Jiang, Li
中科院分区：
文献类型：
--
作者：
Lue, Qingguo;Tong, Nanwei;Jiang, Li
目标：为了解社区糖尿病前期人群胰岛素抵抗（IR）、慢性炎症及尿白蛋白/肌酐比值（ACR）的变化，对252例糖尿病前期（PD，包括空腹血糖受损（IFG）91例，糖耐量减低（IGT）123例，空腹血糖正常（IFG）123例，空腹血糖正常（IGT）123例。从2336名社区个体中筛查了IFG + IGT，38]和38名35岁以上新诊断糖尿病（NDDM）患者。选择123例年龄、性别相匹配的糖耐量正常者作为对照组。结果：PD组、NDDM组、NGT组血清脂联素、白细胞介素6（IL 6）、尿ACR、胰岛素抵抗指数（HOMA-IR）、Gutt's指数差异均有统计学意义（P < 0. 05）。NGT组、PD组和NDDM组的脂联素水平和Gutt's指数逐渐降低，而IL-6水平和ACR逐渐升高（P < 0.01）。与脂联素和IL-6不同，ACR分析显示从NGT、IFG、IGT、IFG + IGT到NDDM患者逐渐升高（P < 0.01）。IFG与NDDM、IFG + IGT与NDDM之间Gutt's指数差异有统计学意义（P < 0.01），而HOMA-IR指数差异无统计学意义。结论：糖尿病前期个体存在IR、慢性炎症和内皮功能障碍，尤其是IFG + IGT人群。在糖尿病前期人群中，Gutt’s指数和ACR作为IR和慢性炎症指标可能比脂联素和HOMA-IR指数更敏感。皇冠版权所有（C）2009由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Aims: To investigate alterations of insulin resistance (IR), chronic inflammation and urine albumin-to-creatinine ratio (ACR) in Chinese community-based prediabetic population.Materials and methods: 252 prediabetics [prediabetes (PD), including impaired fasting glucose (IFG), 91; impaired glucose tolerance (IGT), 123; IFG + IGT, 38] and 38 newly diagnosed-diabetics (NDDM) aged over 35 years older were screened from 2336 community individuals. 123 age and gender matched individuals with normal glucose tolerance (NGT) were selected as controls. Serum adiponectin, interleukin-6 (IL-6) levels and urine ACR were determined, HOMA-IR and Gutt's index were calculated to evaluate IR and insulin sensitivity, respectively.Results: The data displayed significant difference of serum adiponectin, IL-6, ACR and Gutt's index among PD, NDDM and NGT groups. Adiponectin level and Gutt's index decreased, but IL-6 level and ACR increased gradually among NGT, PD and NDDM groups (P < 0.01). Unlike adiponectin and IL-6, ACR analysis indicates a gradual increase from NGT, IFG, IGT, IFG + IGT to NDDM individuals (P < 0.01). Gutt's index showed significant difference between IFG and NDDM, IFG + IGT and NDDM (P < 0.01), but HOMA-IR index did not.Conclusions: IR, chronic inflammation and endothelial dysfunction dose exist in prediabetic individuals, especially in IFG + IGT population. Gutt's index and ACR might seem to be more sensitive than adiponectin and HOMA-IR index as IR and chronic inflammation maker in prediabetic population. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.