Obesity, adipokines, and abdominal aortic aneurysm - Health in men study
Obesity, adipokines, and abdominal aortic aneurysm - Health in men study
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DOI：
10.1161/circulationaha.107.717926
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发表时间：
2007-11-13
期刊：
影响因子：
37.8
通讯作者：
Norman, Paul E.
中科院分区：
文献类型：
--
作者：
Golledge, Jonathan;Clancy, Paula;Norman, Paul E.
肥胖与动脉闭塞性疾病有关，但不被认为是腹主动脉瘤（AAA）的危险因素。我们调查了肥胖，血清脂肪因子，和AAA.Methods和Results-As人口研究的一部分，人体测量之间的关联，我们筛选了12 203名男性65至83岁的AAA使用超声; 875有AAA（>= 30 mm）。记录心血管危险因素和腰围、臀围。在952名男性中测量了血清脂肪因子，其中318名患有AAA。腰围（比值比[ OR]，1.14; 95%置信区间[ CI]，1.06 - 1.22）和腰臀比（OR，1.22; 95% CI，1.09 - 1.37）在调整其他已知风险因素后与AAA独立相关。AAA >= 40 mm的相关性更强（腰臀比：OR，1.53; 95% CI，1.26 - 1.85）.血清β-淀粉样蛋白浓度与AAA（OR，1.53; 95%CI，1.32 - 1.76）和主动脉直径（β =0.19，P < 0.0001）有很强的独立相关性。血清脂联素与AAA ≥ 30 mm相关（OR，1.26; 95% CI，1.07 - 1.50），但与AAA ≥ 40 mm无关（OR，1.03; 95% CI，0.77 - 1.39）。血清瘦素与AAA无关。结论肥胖的措施与AAA独立相关。与与肥胖症密切相关的脂肪因子相比，血清β-淀粉样蛋白浓度与主动脉直径的相关性更强。需要进一步的研究来调查连接的机制，arabin和AAA。
Background-Obesity is associated with occlusive artery disease but is not considered a risk factor for abdominal aortic aneurysm (AAA). We investigated the association between anthropometric measures of obesity, serum adipokines, and AAA.Methods and Results-As part of a population study, we screened 12 203 men 65 to 83 years of age for AAA using ultrasound; 875 had an AAA (>= 30 mm). Cardiovascular risk factors and waist and hip circumference were recorded. Serum adipokines were measured in 952 men, 318 of whom had an AAA. Waist circumference (odds ratio [ OR], 1.14; 95% confidence interval [ CI], 1.06 to 1.22) and waist- to- hip ratio (OR, 1.22; 95% CI, 1.09 to 1.37) were independently associated with AAA after adjustment for other known risk factors. The association was stronger for AAA >= 40 mm (waist- to- hip ratio: OR, 1.53; 95% CI, 1.26 to 1.85). Serum resistin concentration was strongly independently associated with AAA (OR, 1.53; 95% CI, 1.32 to 1.76) and aortic diameter (beta=0.19, P < 0.0001). Serum adiponectin was associated with AAA >= 30 mm (OR, 1.26; 95% CI, 1.07 to 1.50) but not AAA >= 40 mm (OR, 1.03; 95% CI, 0.77 to 1.39). Serum leptin was not associated with AAA.Conclusions-Measures of obesity are independently associated with AAA. Serum resistin concentrations were more strongly associated with aortic diameter than adipokines that are more intimately associated with adiposity. Further studies are required to investigate the mechanisms linking resistin and AAA.