Golgi as an MTOC: making microtubules for its own good.

Golgi as an MTOC: making microtubules for its own good.
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DOI:
10.1007/s00418-013-1119-4
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发表时间:
2013-09
影响因子:
2.3
通讯作者:
Kaverina, Irina
Kaverina, Irina
中科院分区:
生物学3区
文献类型:
--
作者:
Zhu, Xiaodong;Kaverina, Irina

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在细胞中,微管(MT)在MT组织中心(MTOC)成核。基于中心体的MTOC组织径向MT阵列,这通常不是极化运输的最佳选择。最近发现的一个子集的非中心体MT在高尔基体成核已被证明是不可或缺的高尔基体组织,后高尔基体贩运和细胞极性。在这里,我们总结了这一发现的历史、高尔基体MT成核的已知分子先决条件以及高尔基体衍生MT的独特功能。
In cells, microtubules (MTs) are nucleated at MT-organizing centers (MTOCs). The centrosome-based MTOCs organize radial MT arrays which are often not optimal for polarized trafficking. A recently discovered subset of non-centrosomal MTs nucleated at the Golgi has proven to be indispensable for the Golgi organization, post-Golgi trafficking and cell polarity. Here, we summarize the history of this discovery, known molecular prerequisites of MT nucleation at the Golgi and unique functions of Golgi-derived MTs.
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