A novel photoplethysmography technique to derive normalized arterial stiffness as a blood pressure independent measure in the finger vascular bed
A novel photoplethysmography technique to derive normalized arterial stiffness as a blood pressure independent measure in the finger vascular bed
复制标题
一种新颖的光电体积描记技术，可得出标准化动脉硬度，作为手指血管床中独立于血压的测量值
DOI：
10.1088/0967-3334/32/11/003
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发表时间：
2011
期刊：
影响因子：
3.2
通讯作者：
Ohoguro H
中科院分区：
文献类型：
--
作者：
Tanaka G;Yamakoshi K;Sawada Y;Matsumura K;Maeda K;Kato Y;Horiguchi M;Ohoguro H
小动脉硬化可能是动脉硬化的最早征象。然而，没有适当的方法来直接评估小动脉僵硬度。在这项研究中，手指动脉弹性指数（FEI）被定义为参数n，它表示压力（P）-容量（Va）关系的指数模型（Va = a-B exp（-exp））的曲线线性。对于原始估计，FEI是根据闭合手指时手指光电容积描记图的顺应性指数计算的。一个简单的估计FEI的设计，利用归一化的脉搏量，而不是顺应性指数。这两个估计值与健康年轻参与者的指数模型（研究1：n= 19）非常一致。由于FEI依赖于手指平均血压，因此将标准化手指动脉僵硬指数（FSI）定义为两者关系的标准化残差：FSI的平均值和标准差（SD）为50±10（研究2：n= 174）。四次测量的FSI平均变异系数为5.72%（研究3：n= 6）。7例动脉瘤患者的FSI均值和SD为100.0±13.5。因此，简单估算的FEI和FSI是有效的，可用于动脉硬化的研究。
Stiffening of the small artery may be the earliest sign of arteriosclerosis. However, there is no adequate method for directly assessing small arterial stiffness. In this study, the finger arterial elasticity index (FEI) was defined as the parameter n which denotes the curvilinearity of an exponential model of pressure (P)–volume (V a) relationship (V a= a− b exp (− nP)). For the original estimation, the FEI was calculated from a compliance index from the finger photoplethysmogram whilst occluding the finger. A simple estimation of the FEI was devised by utilizing normalized pulse volume instead of the compliance index. Both estimations yielded close agreement with the exponential model in healthy young participants (study 1: n= 19). Since the FEI was dependent on finger mean blood pressure, normalized finger arterial stiffness index (FSI) was defined as standardized residual from their relationship: mean and standard deviation (SD) of the FSI were 50±10 (study 2: n= 174). The mean coefficient of variation of the FSI for four measurements was 5.72%(study 3: n= 6). The mean and SD of the FSI in seven arteriosclerotic patients were 100.0±13.5. In conclusion, the FEI and FSI by simple estimation are valid and useful for arteriosclerosis research.