Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children
Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children
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DOI：
10.1038/srep31727
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发表时间：
2016-08-17
影响因子：
4.6
通讯作者：
Hoffman, Eric P.
中科院分区：
文献类型：
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作者：
Hathout, Yetrib;Conklin, Laurie S.;Hoffman, Eric P.
皮质类固醇广泛用于儿科，但副作用的负担是显着的。类固醇药物药效学的简单、快速和可靠的生化读数的可用性可以快速和客观地评估皮质类固醇的安全性和有效性，并有助于皮质类固醇替代药物的开发。为了鉴定潜在的皮质类固醇响应性生物标志物，我们使用SOMAscan适体组对来自有和没有皮质类固醇治疗的DMD和IBD患者的血清样品进行蛋白质组分析，测试了1，129种蛋白质，
Corticosteroids are extensively used in pediatrics, yet the burden of side effects is significant. Availability of a simple, fast, and reliable biochemical read out of steroidal drug pharmacodynamics could enable a rapid and objective assessment of safety and efficacy of corticosteroids and aid development of corticosteroid replacement drugs. To identify potential corticosteroid responsive biomarkers we performed proteome profiling of serum samples from DMD and IBD patients with and without corticosteroid treatment using SOMAscan aptamer panel testing 1,129 proteins in