Run4Love, a mHealth (WeChat-based) intervention to improve mental health of people living with HIV: a randomized controlled trial protocol.
Run4Love, a mHealth (WeChat-based) intervention to improve mental health of people living with HIV: a randomized controlled trial protocol.
复制标题
Run4Love，一项旨在改善艾滋病毒感染者心理健康的 mHealth（基于微信）干预措施：一项随机对照试验方案
DOI：
10.1186/s12889-018-5693-1
复制
发表时间：
2018-06-26
影响因子：
4.5
通讯作者：
Yang C
中科院分区：
文献类型：
--
作者：
Guo Y;Hong YA;Qiao J;Xu Z;Zhang H;Zeng C;Cai W;Li L;Liu C;Li Y;Zhu M;Harris NA;Yang C
背景艾滋病毒携带者(PLWH)患有高比例的精神疾病；但有针对性的有效干预措施有限，特别是在发展中国家。智能手机使用的高渗透率和社交媒体应用的广泛接受为中国这样的资源有限环境下的基于移动的健康干预(mHealth干预)提供了前所未有的机会。本文介绍了旨在改善中国PLWH患者心理健康的Run4Love随机对照试验(RCT)的设计和样本特征。干预组参与者接受了增强型微信平台提供的适应性认知-行为压力管理课程(为期3个月)，并激发了他们参与体育活动的动机。通过及时反馈和奖励，自动跟踪和监测参与者的进展情况。对照组除了标准护理外，还收到了一本关于PLWH营养的小册子。使用平板电脑在基线、3个月、6个月和9个月进行结果评估。主要结果是抑郁症状由流行病学研究中心抑郁量表(CES-D)衡量。次要结果包括生活质量、用毛发皮质醇生物标记物测量的慢性压力，以及其他衡量压力和抑郁、自我效能、应对、艾滋病毒相关耻辱、体力活动和患者满意度的指标。讨论Run4Love研究是首批开发和评估多成分、集成的mHealth干预措施以改善PLWH心理健康和生活质量的努力之一。一旦被证明有效，Run4Love可以扩大规模，并有可能整合到PLWH的常规病例管理中，并适用于其他慢性病患者。试验注册中国临床试验注册-CHICCTR-IPR-17012606，于2017年9月7日注册。
BackgroundPeople living with HIV (PLWH) suffer from high rates of mental illness; but targeted effective interventions are limited, especially in developing countries. High penetration of smartphone usage and widespread acceptance of social media applications provide an unprecedented opportunity for mobile-based health interventions (mHealth interventions) in resource-limited settings like China. The current report describes the design and sample characteristics of the Run4Love randomized controlled trial (RCT) aimed at improving mental health in PLWH in China.MethodsA total of 300 PLWH with elevated depressive symptoms were recruited and randomized into either the intervention or control group. Participants in the intervention group received an adapted cognitive-behavioral stress management (CBSM) course delivered by the enhanced WeChat platform (for 3 months) and were motivated to engage in physical activities. Progress of the participants was automatically tracked and monitored with timely feedback and rewards. The control group received a brochure on nutrition for PLWH in addition to standard care. The outcome assessments are conducted at baseline, 3, 6, and 9 months using tablets. The primary outcome is depressive symptoms measured by the scale of the Center for Epidemiology Studies Depression (CES-D). Secondary outcomes include quality of life, chronic stress measured with biomarker of hair cortisol, and other measures of stress and depression, self-efficacy, coping, HIV-related stigma, physical activity, and patient satisfaction. Mixed effects model with repeated measures (MMRM) will be used to analyze the intervention effects.DiscussionThe Run4Love study is among the first efforts to develop and evaluate a multicomponent and integrated mHealth intervention to improve the mental health and quality of life of PLWH. Once proven effective, Run4Love could be scaled up and potentially integrated into the routine case management of PLWH and adapted to other populations with chronic diseases.Trial registrationChinese Clinical Trial Registry - ChiCTR-IPR-17012606 , registered on 07 September 2017.
登录
查看更多内容
影响因子：
7.4
作者：
Cao B;Liu C;Durvasula M;Tang W;Pan S;Saffer AJ;Wei C;Tucker JD
通讯作者：
Tucker JD
影响因子：
3.3
作者：
Antoni, MH;Carrico, AW;Schneiderman, N
通讯作者：
Schneiderman, N
影响因子：
168.9
作者：
Lester, Richard T.;Ritvo, Paul;Plummer, Francis A.
通讯作者：
Plummer, Francis A.
影响因子：
1.7
作者：
Ahaneku H;Ross MW;Nyoni JE;Selwyn B;Troisi C;Mbwambo J;Adeboye A;McCurdy S
通讯作者：
McCurdy S
影响因子：
7.4
作者：
Hong YA;Zhou Z;Fang Y;Shi L
通讯作者：
Shi L