FUNDAMENTAL IMPORTANCE OF ARTERIAL OXYGEN-CONTENT IN THE REGULATION OF CEREBRAL BLOOD-FLOW IN MAN
FUNDAMENTAL IMPORTANCE OF ARTERIAL OXYGEN-CONTENT IN THE REGULATION OF CEREBRAL BLOOD-FLOW IN MAN
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DOI：
10.1093/brain/108.1.81
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发表时间：
1985-01-01
期刊：
影响因子：
14.5
通讯作者：
MARSHALL, J
中科院分区：
文献类型：
--
作者：
BROWN, MM;WADE, JPH;MARSHALL, J
在54例血红蛋白浓度变化引起动脉血氧含量变化的受试者中研究了脑血流量（CBF）、动脉血氧含量、全血粘度和氧向脑的运输之间的关系，范围为5.7 - 19.1 g/dl。CBF和动脉血氧含量之间存在高度显著的相关性，CBF的改变使氧向脑的运输速率保持在一定的限度内。血液粘度变化无显著影响。在多元回归分析中，动脉氧含量成为CBF的主要决定因素，考虑到这种影响后，血液粘度、动脉pCO 2、年龄或平均动脉血压均无显著影响。结果表明，在贫血和红细胞增多症患者中发现的CBF变化主要是生理性的，而不是由血液粘度的伴随变化引起的。有人提出，脑循环动脉氧含量的反应是由一个局部机制介导的敏感改变局部组织氧张力。
The relationships between cerebral blood flow (CBF), arterial oxygen content, whole blood viscosity and the transport of oxygen to the brain have been studied in 54 subjects with variations in arterial oxygen content resulting from alterations in haemoglobin concentration ranging from 5.7 to 19.1 g/dl. A highly significant relationship was found between CBF and arterial oxygen content, CBF altering to maintain the rate of transport of oxygen to the brain within certain limits. No significant effect of changes in blood viscosity was evident. In a multiple regression analysis arterial oxygen content emerged as the major determinant of CBF and after this effect had been taken into account there was no significant influence of blood viscosity, arterial pCO2, age or mean arterial blood pressure. The results imply that the alterations in CBF found in subjects with anaemia and polycythaemia are primarily physiological and not caused by the accompanying alterations in blood viscosity. It is proposed that the response of the cerebral circulation to arterial oxygen content is mediated by a local mechanism sensitive to alterations in local tissue oxygen tension.