The Leptin Signaling
The Leptin Signaling
复制标题
瘦素信号传导。
DOI：
10.1007/978-981-13-1286-1_7
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Zheng, Ruimao
中科院分区：
文献类型：
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作者：
Liu, Jiarui;Yang, Xiaoning;Zheng, Ruimao
瘦素在能量平衡和代谢稳态的调节中起着至关重要的作用。瘦素信号传导受损与肥胖和代谢性疾病（包括糖尿病、心血管疾病等）的发病机制密切相关。瘦素在中枢神经系统表达瘦素受体的神经元中启动其细胞内信号传导，发挥生理功能，从而导致食欲抑制、食物摄入减少、促进线粒体氧化、产热增强和体重下降。本文对瘦素神经细胞通路的研究进行综述，重点介绍近10年来的进展，以期更好地理解肥胖等代谢性疾病的分子机制。
Leptin plays a critical role in the regulation of energy balance and metabolic homeostasis. Impairment of leptin signaling is closely involved in the pathogenesis of obesity and metabolic diseases, including diabetes, cardiovascular disease, etc. Leptin initiates its intracellular signaling in the leptin-receptor-expressing neurons in the central nervous system to exert physiological function, thereby leading to a suppression of appetite, a reduction of food intake, a promotion of mitochondrial oxidation, an enhancement of thermogenesis, and a decrease in body weight. In this review, the studies on leptin neural and cellular pathways are summarized with an emphasis on the progress made during the last 10 years, for better understanding the molecular mechanism of obesity and other metabolic diseases.