Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approaches
Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approaches
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DOI：
10.1017/s1355617707070671
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发表时间：
2007-05-01
影响因子：
2.6
通讯作者：
Rao, Stephen M.
中科院分区：
文献类型：
--
作者：
Hinton, Sean C.;Paulsen, Jane S.;Rao, Stephen M.
亨廷顿氏病（HD）是一种神经退行性疾病，临床诊断为舞蹈样运动的发展。然而，神经心理学研究已经证明了在正式诊断之前的临床前阶段（pre-HD）期间的认知和精神变化。先前的研究已经证明了时间再现任务对基底神经节病理的敏感性，如在临床HD和帕金森病中所见。在这项研究中，29个预HD参与者，从3至39年估计发病（YEO）的HD的基础上的基因检测和实足年龄，管理的节奏手指敲击任务，使用目标间隔600和1200毫秒。平均反应间的时间间隔，时间准确性的措施，没有系统地偏离目标间隔作为YEO的函数。与此相反，时间变异性增加curvilinearly作为YEO的函数，但不与实足年龄。运动计时变异性，而不是准确性，可以作为一个标记，以确定最早的行为变化，在HD。本研究是第一个研究行为措施和YEO之间的关系，在前HD。
Huntington's disease (HD) is a neurodegenerative disorder diagnosed clinically with the development of choreiform movements. However, neuropsychological studies have demonstrated cognitive and psychiatric changes during the preclinical phase (pre-HD) prior to formal diagnosis. Previous studies have demonstrated the sensitivity of time reproduction tasks to basal ganglia pathology, as seen in clinical HD and Parkinson's disease. In this study, 29 pre-HD participants, ranging from 3 to 39 years from estimated onset (YEO) of HD based on genetic testing and chronological age, were administered the paced finger-tapping task using target intervals of 600 and 1200 ms. Mean inter-response interval, a measure of timing accuracy, did not systematically deviate from the target interval as a function of YEO. In contrast, timing variability increased curvilinearly as a function of YEO, but not with chronological age alone. Motor timing variability, but not accuracy, may serve as a marker to define the earliest behavioral changes in HD. The present study is among the first to examine the relationship between behavioral measures and YEO in pre-HD.