The association between cannabis use and anxiety disorders: Results from a population-based representative sample
The association between cannabis use and anxiety disorders: Results from a population-based representative sample
复制标题
DOI：
10.1016/j.euroneuro.2015.12.037
复制
发表时间：
2016-03-01
影响因子：
5.6
通讯作者：
Lev-Ran, Shaul
中科院分区：
文献类型：
--
作者：
Feingold, Daniel;Weiser, Mark;Lev-Ran, Shaul
大麻使用与焦虑症之间的横向关联已有充分记录，但对两者之间的纵向关联知之甚少。这项研究在一项为期 3 年的前瞻性研究中探讨了大麻使用、大麻使用障碍 (CUD) 和焦虑症之间的关联。数据取自国家酒精及相关疾病流行病学调查 (NESARC) 第 1 波和第 2 波。焦虑症，包括广泛性焦虑症、社交焦虑症、恐慌症和特定恐惧症，在基线时得到控制。开始使用大麻被定义为前终生戒烟者在基线和随访期间使用任何大麻，CUD 被定义为大麻滥用或依赖的诊断。结果表明，大麻的使用与任何焦虑症的发病率增加无关（调整优势比（AOR）= 1.12（0.63-0.98））。尽管在大多数模型中，大量使用大麻与社交焦虑发生率增加有关，但最终调整后的模型中并未完全保留这一点（AOR=1.98（0.99-1.98））。对基线 CUD 与随访时焦虑症之间关联的调查显示了类似的结果。任何基线焦虑症与未来开始使用大麻 (AOR=1.03(0.62-1.69)) 或 CUD 发作 (AOR=0.68(0.41-1.14)) 无关，但患有基线恐慌症的个体更倾向于在随访时开始使用大麻 (AOR=2.2(1.15-4.18))，可能作为一种自我药疗手段。我们的研究结果表明，大麻使用和 CUD 与大多数焦虑症发病率增加无关，相反，大多数焦虑症与大麻使用或 CUD 发病率增加无关。 (C) 2015 Elsevier B.V. 和 ECNP。版权所有。
The cross-sectional association between cannabis use and anxiety disorders is well documented, yet less is known about the longitudinal association between the two. This study explored the association between cannabis use, cannabis use disorders (CUDs) and anxiety disorders in a 3 year prospective study. Data was drawn from waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Anxiety disorders, including generalized anxiety disorder, social anxiety, panic disorder and specific phobias, were controlled for at baseline. Initiation of cannabis use was defined as any cannabis use by former lifetime abstainers in the time period between baseline and follow-up, CUDs were defined as a diagnosis of cannabis abuse or dependence. Results indicate that cannabis use was not associated with increased incidence of any anxiety disorder (Adjusted Odds Ratio (AOR)=1.12(0.63-0.98)). Though heavy cannabis use was associated with increased incidence of social anxiety in most models, this was not fully retained in the final adjusted model (AOR=1.98(0.99-1.98)). Investigation of the association between baseline CUDs and anxiety disorders at follow-up revealed similar results. Any baseline anxiety disorder was not associated with future initiation of cannabis use (AOR=1.03(0.62-1.69)) or onset of a CUD (AOR=0.68(0.41-1.14)), yet individuals with baseline panic disorder were more prone to initiate cannabis use at follow-up (AOR=2.2(1.15-4.18)), possibly as a means of self-medication. Our findings suggest that cannabis use and CUDs are not associated with increased incidence of most anxiety disorders and inversely, most anxiety disorders are not associated with increased incidence of cannabis use or CUDs. (C) 2015 Elsevier B.V. and ECNP. All rights reserved.