Effects of ddt homologs administered to female rats during the perinatal period.
Effects of ddt homologs administered to female rats during the perinatal period.
复制标题
在围产期给予雌性大鼠滴滴涕同系物的影响。
DOI：
10.1159/000240740
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
LeRoy Heinrichs
中科院分区：
文献类型：
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作者：
Ronald J. Gellert;LeRoy Heinrichs
雌性大鼠在围产期给予雌激素可诱导下丘脑分化的阳性模式，导致持续阴道发情（PVE）和无排卵。从妊娠第15-19天开始，通过管饲法给予10 mg/天的雌激素同系物o，p-DDT、o，p-DDE和dda，以及据称非雌激素形式的杀虫剂p，p-DDT和o，p-DDD。雌性大鼠在出生后第二、第三和第四天也每天给予SQ 1 mg剂量的同系物。在用o，p-DDD灌胃的母鼠中，阴道开放延迟2天。定期检查用o，p-DDD经阴道给药的大鼠的发情周期，发现209日龄时PVE，258日龄时无黄体。在4月龄之前，这些动物的发情周期正常。其余的农药同系物测试，无论管理模式，没有显着影响发情周期或内分泌腺重量。
The administration of estrogen to female rats during the perinatal period induces a masculine pattern of hypothalamic differentiation resulting in persistent vaginal estrus (PVE) and anovulation. 10 mg day of the estrogenic homologs o,p-DDT, o,p-DDE, and dda, as well as allegedly nonestrogenic forms of the pesticide, p,p-DDT and o,p-DDD, were given by gavage from days 15-19 of pregnancy. 1-mg doses of the homologs were also given SQ daily to female rats on the second, third, and fourth days of life. Vaginal opening was delayed by 2 days in rats derived from the dams gavaged with o,p-DDD. Periodic examination of estrous cycles in the rats treated neonatally with o,p-DDD revealed PVE by 209 days of age, and absence of corpora lutea by 258 days of age. Prior to 4 months of age, estrous cycles were normal in these animals. The remaining pesticide homologs tested, regardless of the mode of administration, had no significant effect on the estrous cycles or on endocrine gland weights.