Dietary patterns and the risk of breast cancer
Dietary patterns and the risk of breast cancer
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DOI：
10.1016/j.annepidem.2005.01.008
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发表时间：
2005-11-01
影响因子：
5.6
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Adebamowo, CA;Hu, FB;Willett, WC
目的：研究表明，西方饮食与乳腺癌风险之间存在关联。我们检查了护士健康研究II的数据，以评估主要饮食模式和绝经前妇女乳腺癌风险之间的关联。方法：我们从90,638名绝经前妇女的反应中得出“西方”和“谨慎”的饮食模式，年龄在1991年基线时为26至46岁，他们在1991年和1995年完成了有效的食物频率问卷。这些模式，然后评估其与乳腺癌的风险。结果：在8年的随访中，我们记录了710例浸润性乳腺癌。累积平均分最高与最低五分位数比较的多变量RR（95%CI）为0.90（0.68-1.18，p值，趋势检验= 0.54），对于谨慎饮食模式和0.97（0.71-1.33，p值，趋势检验= 0.97）。结论：我们的研究结果表明，饮食模式和乳腺癌风险之间没有总体关联。然而，我们发现在曾经吸烟者中，谨慎的饮食模式和乳腺癌风险之间存在负相关，但相互作用的检验并不显著。我们认为这一发现值得进一步评估。
PURPOSE: Ecologic, migrant, and secular trend studies suggest an association between the Western diet and the risk of breast cancer. We examined data from the Nurses Health Study II to evaluate the association between major dietary patterns and the risk of breast cancer among pre-menopausal women.METHODS: We derived "Western" and "prudent" dietary patterns from the responses of 90,638 premenopausal women, aged 26 to 46 years at baseline in 1991, who completed validated food frequency questionnaires in 1991 and 1995. These patterns were then evaluated for their associations with risk of breast cancer.RESULTS: During 8 years of follow-up, we documented 710 cases of invasive breast cancer. The multivariate RR (95% CI) comparing highest to lowest quintiles of cumulative average score were 0.90 (0.68-1.18, p-value, test for trend = 0.54) for the prudent dietary pattern and 0.97 (0.71-1.33, p-value, test for trend = 0.97) for the Western dietary pattern.CONCLUSIONS: Our findings suggest that there is no overall association between dietary patterns and risk of breast cancer. However, we found an inverse association between the prudent dietary pattern and breast cancer risk among ever smokers, but the test for interaction was not significant. We suggest that this finding merits further evaluation.