Synergistic thermoradiotherapy based on PEGylated Cu3BiS3 ternary semiconductor nanorods with strong absorption in the second near-infrared window
Synergistic thermoradiotherapy based on PEGylated Cu3BiS3 ternary semiconductor nanorods with strong absorption in the second near-infrared window
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基于第二近红外窗口强吸收的聚乙二醇化Cu3BiS3三元半导体纳米棒的协同热放射治疗
DOI：
10.1016/j.biomaterials.2016.10.024
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发表时间：
2017-01-01
期刊：
影响因子：
14
通讯作者：
Li, Wanwan
中科院分区：
文献类型：
--
作者：
Li, Ang;Li, Xiang;Li, Wanwan
在本工作中，我们成功地合成了从紫外光(UV)到近红外(NIR)波长范围内具有宽而强的光吸收的铜铋硫化物纳米棒(NRS)，它可以作为1064 nm激光驱动的光热剂，其光热转换效率为40.7%，显著高于已报道的大多数工作在NIR-II窗口的FIT试剂。制备的聚乙二醇化的Cu3BiS3纳米微粒由于其对铋的强近红外吸收和较大的X射线衰减系数，被用作光声成像(PAD)和CT成像剂。我们首次证明了肿瘤中少量的聚乙二醇化的Cu3BiS3 NRs在近红外II辐射下可以集中辐射能量并触发温和的PTT，因此，这些颗粒可以被用作一种新型的、协同的热放射治疗剂，从而提高放射治疗的疗效。(C)2016爱思唯尔有限公司。保留所有权利。
In this work, we report a successful synthesis of copper bismuth sulfide nanorods (NRs) with broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, which can be used as a 1064 nm-laser-driven photothermal agent with the photothermal conversion efficiency of 40.7%, noticeably higher than most of the reported FIT agents working in NIR-II window. The as prepared PEGylated Cu3BiS3 NRs were used as photoacoustic imaging (PAD and CT imaging agents due to their strong NIR absorption and large X-ray attenuation coefficient of bismuth. We are the first to demonstrate that a small quantity of PEGylated Cu3BiS3 NRs in tumors can concentrate radiation energy and trigger mild PTT under NIR-II irradiation and thus, these particles could be used as a novel, synergistic thermoradiotheraputic agent that enhances the efficacy of radiotherapy. (C) 2016 Elsevier Ltd. All rights reserved.