MECHANICS OF CANINE DIAPHRAGM
MECHANICS OF CANINE DIAPHRAGM
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DOI：
10.1152/jappl.1976.41.3.369
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发表时间：
1976-01-01
影响因子：
3.3
通讯作者：
SHARP, JT
中科院分区：
文献类型：
--
作者：
KIM, MJ;DRUZ, WS;SHARP, JT
使用2种技术评估麻醉犬的膈肌力-长度行为。一个采用测量在一个完整的神经和血液供应的隔膜带;第二个相关的transmatic压力（Pdi），以直接估计在双边，强直，超大膈神经刺激期间从应变计拱的张力。在条带制备中，隔膜在短至静止原位长度（L0）的40%的长度处施加主动力，并且在平均比L0大25%的长度处记录最大力。这表明与其他骨骼肌相比，横膈膜的有效长度范围更宽。在完整的准备中，Pdi和直接测量的血管张力都与肺容量呈负相关;当它们用于计算血管的有效曲率半径（r）时，r变化很小或在肺容量大时下降，而不是像理论预测的那样增加。在解释正常狗和可能正常人的骨骼肌功能时，长度-张力特征显然超过了几何考虑。
Diaphragmatic force-length behavior was assessed in anesthetized dogs using 2 techniques. One employed measurements in a diaphragm strip with intact nerve and blood supply; the 2nd related transdiaphragmatic pressure (Pdi) to direct estimates of diaphragmatic tension from strain gauge arches during bilateral, tetanic, supramaximal phrenic nerve stimulation. In strip preparations the diaphragm exerted active force at lengths as short as 40% of resting in situ length (L0) and maximal force was registered at a length averaging 25% greater than L0. This suggested a broader effective length range for the diaphragm as compared to other skeletal muscles. In the intact preparation, both Pdi and directly measured diaphragmatic tension were inversely related to lung volume; when they were used to calculate the diaphragm''s effective radius of curvature (r), r changed little or decreased at large lung volumes rather than increase as theory would predict. Length-tension characteristics apparently outweighed geometric considerations in explaining the diaphragm''s function in normal dogs and probably normal men.