Fatigue and declines in cognitive functioning in multiple sclerosis
Fatigue and declines in cognitive functioning in multiple sclerosis
复制标题
DOI：
10.1212/wnl.55.7.934
复制
发表时间：
2000-10-10
期刊：
影响因子：
9.9
通讯作者：
Elkins, LE
中科院分区：
文献类型：
--
作者：
Krupp, LB;Elkins, LE
目的：确定认知疲劳能否在多发性硬化症中被识别出来。方法：45名多发性硬化症患者和14名健康对照受试者完成了4小时的认知测试，包括基线神经心理测验、持续努力的认知任务(在电脑上完成心算问题)和重复的神经心理测验。在测试过程的每一步之前，都完成了疲劳和情绪的自我报告测量。结果：多发性硬化症患者和对照组受试者在测试过程中认知表现的变化模式明显不同。患有多发性硬化症的人在言语记忆和概念规划方面表现出下降，而对照组参与者表现出改善。尽管两组在任何一项基线认知测量上都没有显著差异，但多发性硬化症参与者在持续努力的认知任务后重复的视觉记忆、言语记忆和言语流畅性测试中的表现逊于对照组。MS和对照组参与者都报告说，与他们的基准值相比，在整个测试过程中，精神和身体疲劳都有所增加。结论：多发性硬化症患者在一次测试中表现出认知能力的下降，并且没有表现出健康对照受试者的改善。
Objective: To determine whether cognitive fatigue, defined as a decline in cognitive performance over a single testing session, could be identified in MS. Methods: Forty-five individuals with MS and 14 healthy control participants completed a 4-hour session of cognitive testing that involved a baseline neuropsychological battery, a continuous effortful cognitive task (completing mental arithmetic problems administered on a computer), and a repeat neuropsychological battery. Self-report measures of fatigue and affect were completed before each step of the testing session. Results: The pattern of change in cognitive performances over the testing session significantly differed between the MS and control participants. Individuals with MS showed declines on measures of verbal memory and conceptual planning, whereas the control participants showed improvement. Although there were no significant differences between the groups on any of the baseline cognitive measures, the MS participants performed worse than the control subjects on tests of visual memory, verbal memory, and verbal fluency that were repeated following the continuous effortful cognitive task. Both MS and control participants reported increased mental and physical fatigue across the testing session compared with their baseline values. Conclusion: Individuals with MS show declines in cognitive performance during a single testing session and fail to show the improvement exemplified by healthy control subjects.