Social phobia: diagnosis and epidemiology, neurobiology and pharmacology, comorbidity and treatment
Social phobia: diagnosis and epidemiology, neurobiology and pharmacology, comorbidity and treatment
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DOI：
10.1016/s0165-0327(99)00140-8
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发表时间：
2000-10-01
影响因子：
6.6
通讯作者：
Wittchen, HU
中科院分区：
文献类型：
--
作者：
Brunello, N;den Boer, JA;Wittchen, HU
社交恐惧症是一种常见的伴有严重心理社会损害的疾病，其高患病率和终身慢性化是一个重要的公共卫生问题。社交恐惧症开始于儿童早期或青春期，通常与抑郁症，其他焦虑症，酒精和药物滥用或饮食失调共病。这：级联的合并症，通常继发于社交恐惧症，增加了与病情相关的残疾。社交恐惧症可能是后来发展为共病障碍的触发因素，这一可能性促使人们关注早期有效治疗作为预防措施的必要性。他最近研究的用于社交恐惧症心理药理学治疗的药物类别是SSRI组，支持率越来越高。已评估的其他药物类别是单胺氧化酶抑制剂（MAOI），苯二氮卓类和β-受体阻滞剂，SSRI代表了广泛社交恐惧症患者的一种新的有吸引力的治疗选择。最近完成了第一次大规模安慰剂对照研究，以评估帕罗西汀对广泛性社交恐怖症的药物治疗效果，帕罗西汀在减轻症状方面比安慰剂更有效，并且耐受性良好。现在许多人认为SSRIs是社交恐惧症的首选药物，因为它们的有效性，因为它们避免了苯二氮卓类药物或经典MAOIs治疗的问题。(C)2000 Elsevier Science B. V.保留所有权利。
Social phobia is a common disorder associated with significant psychosocial impairment, representing a substantial public health problem largely determined by the high prevalence, and the lifelong chronicity. Social phobia starts in early childhood or adolescence and is often comorbid with depression, other anxiety disorders, alcohol and substance abuse or eating disorders. This: cascade of comorbidity, usually secondary to social phobia, increases the disability associated with the condition. The possibility that social phobia may be a trigger for later developing comorbid disorders directs attention to the need for early effective treatment as a preventive measure.The most recent drug class to he investigated for the psychopharmacological treatment of social phobia is the SSRI group for which there is growing support. The other drugs classes that have been evaluated are monoamine oxidase inhibitors (MAOIs), benzodiazepines, and beta-blockers, The SSRIs represent a new and attractive therapeutic choice for patients with generalized social phobia. Recently the fil st, large scale, placebo-controlled study to assess the efficacy of drug treatment in generalized social phobia has been completed with paroxetine, Paroxetine was more effective in reducing the symptoms than placebo and was well tolerated. Many now regard SSRIs as the drugs of choice in social phobia because of their effectiveness and because they avoid the problems of treatment with benzodiazepines or classical MAOIs. (C) 2000 Elsevier Science B.V. All rights reserved.