Pulmonary Vascular Response Patterns to Exercise: Is there a Role for Pulmonary Arterial Pressure Assessment during Exercise in the Post-Dana Point Era?
Pulmonary Vascular Response Patterns to Exercise: Is there a Role for Pulmonary Arterial Pressure Assessment during Exercise in the Post-Dana Point Era?
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DOI：
10.21693/1933-088x-9.2.92
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发表时间：
2010-04-01
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影响因子：
--
通讯作者：
Lewis, Gregory D
中科院分区：
文献类型：
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作者：
Lewis, Gregory D
肺动脉高压（PH）通常在其病程后期诊断，此时其预后特别差。运动可以有效地揭示几种心肺疾病的早期形式，但运动期间进行肺动脉压测量在评估PH中的作用仍不清楚。运动期间肺动脉压力-血流关系是否可以为功能显著的肺动脉高压和左心室功能障碍的早期诊断提供一个窗口，1或增加我们的诊断测试和PH预后指标的工具箱，是正在进行的积极研究的主题。有证据表明，运动时肺动脉压的异常反应模式，当适当地索引到血流量增加时，可能有助于识别心力衰竭和肺动脉高压的早期形式。本文将讨论在运动过程中进行血流动力学测量的方法，以及识别运动正常和异常肺血管反应模式的潜在临床应用。
Pulmonary hypertension (PH) is often diagnosed late in its course when it purports a particularly poor prognosis. Exercise effectively unmasks early forms of several cardiopulmonary diseases but the role of performing pulmonary arterial pressure measurements during exercise in the evaluation of PH remains unclear. Whether pulmonary arterial pressure-flow relationships during exercise may provide a window into earlier diagnosis of functionally significant pulmonary arterial hypertension and left ventricular dysfunction,1 or add incrementally to our armentarium of diagnostic tests and prognostic indicators in PH, is the topic of active ongoing investigation. Evidence is emerging that abnormal pulmonary arterial pressure response patterns to exercise, when properly indexed to increased blood flow, may help to identify early forms of heart failure and pulmonary arterial hypertension. This article will discuss approaches to performing hemodynamic measurements during exercise as well as the potential clinical utility of identifying normal and abnormal pulmonary vascular response patterns to exercise.