The renal tubular handling of aldosterone and its acid-labile conjugate.
The renal tubular handling of aldosterone and its acid-labile conjugate.
复制标题
醛固酮及其酸不稳定结合物的肾小管处理。
DOI：
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发表时间：
1968
影响因子：
15.9
通讯作者：
K. Barry
中科院分区：
文献类型：
--
作者：
M. Scurry;L. Shear;K. Barry
在5只恒河猴身上进行了注射醛固酮-(3)H或其(3)H酸不稳定缀合物的停流研究。在相同的远端尿液样本中，醛固酮-(3)H尿-血浆（U/P）比下降。(3)H酸不稳定的偶联物U/P与菊粉的U/P比值在更近的样品中增加，无论是在醛固酮-(3)H输注过程中内源性形成的偶联物还是单独输注标记的偶联物。醛固酮的重吸收发生在肾小管的远端部位，其酸不稳定的偶联物的分泌发生在近端部位。
Stop-flow studies using infusions of aldosterone-(3)H or its (3)H acid-labile conjugate were done on five rhesus monkeys. The aldosterone-(3)H urine-to-plasma (U/P) ratio decreased in the same distal urine samples as sodium. The (3)H acid-labile conjugate U/P-to-inulin U/P ratio increased in the more proximal samples either with conjugate formed endogenously during aldosterone-(3)H infusions or with labeled conjugate infused alone. Aldosterone reabsorption occurred at a distal site in the renal tubule, and secretion of its acid-labile conjugate occurred at a proximal site.