Classical conditioning of the rabbit eyelid response with a mossy-fiber stimulation CS: II. Lateral reticular nucleus stimulation.
Classical conditioning of the rabbit eyelid response with a mossy-fiber stimulation CS: II. Lateral reticular nucleus stimulation.
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DOI：
10.1037//0735-7044.101.5.676
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发表时间：
1987-10
影响因子：
1.9
通讯作者：
D. Lavond;B. Knowlton;J. Steinmetz;R. Thompson
中科院分区：
文献类型：
--
作者：
D. Lavond;B. Knowlton;J. Steinmetz;R. Thompson
在经典的眼睑/瞬膜反应(NM)条件反射过程中，刺激脑桥核苔藓纤维可作为条件刺激(CS)。在本实验中，我们刺激苔藓纤维的另一个来源--外侧网状核(LRN)，作为NM条件反射的CS。LRN刺激是一种有效的CS，导致学习，对LRN刺激的条件性反应表现为正常消退。CS和UCS的不成对呈现不会导致假性条件反射。小脑齿状回-间位区的损伤消除了条件性反应，但保留了非条件性反射反应。我们认为苔藓纤维可能正常地将CS信息传递到小脑。
Stimulation of mossy fibers arising from the pontine nuclei can be used as a conditioned stimulus (CS) during classical conditioning of the eyelid/nictitating membrane response (NM). In the present experiment we stimulated another source of mossy fibers, the lateral reticular nucleus (LRN), as a CS for NM conditioning. LRN stimulation was an effective CS, resulting in learning, and the conditioned response to LRN stimulation showed normal extinction. Unpaired presentation of CS and UCS did not result in pseudo-conditioning. Lesions of the cerebellar dentate-interpositus region abolished the conditioned response but left the unconditioned reflex response intact. We suggest that mossy fibers may normally carry CS information to the cerebellum.