Delayed reversal of impaired vasodilation in congestive heart failure after heart transplantation.
Delayed reversal of impaired vasodilation in congestive heart failure after heart transplantation.
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心脏移植后充血性心力衰竭受损血管舒张的延迟逆转。
DOI：
10.1016/0002-9149(88)90129-4
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Zelis,R
中科院分区：
文献类型：
--
作者：
Sinoway,LI;Minotti,JR;Davis,D;Pennock,JL;Burg,JE;Musch,TI;Zelis,R
研究了中枢心血管功能变化对外周血管舒张的影响。应用应变计体积描记术测量10例重度充血性心力衰竭患者前臂动脉闭塞解除后的最大血流反应及原位心脏移植前后两次的反应性充血血流峰值（ml/min·100 ml）。2例移植后研究分别在出院前（平均移植后18天）和出院后（平均移植后114天）进行。移植导致最大血管舒张显著但延迟增加（反应性充血：移植前21±3；出院前25±2；出院后43±5），同时前臂最小阻力显著降低。虽然外周血管舒张功能的改善可能与心功能的改善有关，但这种联系不是直接的，也不是立即的。如果最大代谢血流量的正常化与出院后恢复正常的身体活动有关，那么充血性心力衰竭血管舒张能力的大部分基本异常可能与身体状况的改善有关。
The effects of changes in central cardiovascular function on peripheral vasodilation were investigated. Strain gauge plethysmography was used to measure the maximal blood flow response following release of forearm arterial occlusion and the peak reactive hyperemic blood flow response (ml/min · 100 ml) before and twice after orthotopic heart transplantation in 10 subjects with severe congestive heart failure. The 2 posttransplantation studies were done before hospital discharge (mean 18 days after transplantation) and again after discharge (mean 114 days after transplantation). Transplantation led to a significant but delayed increase in maximal vasodilation (reactive hyperemic blood flow: pretransplant 21 ± 3; predischarge 25 ± 2; postdischarge 43 ± 5) and a concurrent significant reduction in minimal forearm resistance. Although the improvement in peripheral vasodilator function may be linked to improvement in cardiac function, this linkage is not direct, nor is it immediate. If the normalization of maximal metabolic blood flow is related to resumption of normal physical activity post-discharge, then much of the basic abnormality in vasodilator capacity in congestive heart failure may be related to physical deconditioning.