A cellular oscillator model for periodic pattern formation
A cellular oscillator model for periodic pattern formation
复制标题
DOI：
10.1006/jtbi.2001.2414
复制
发表时间：
2001-11-21
影响因子：
2
通讯作者：
Goodwin, BC
中科院分区：
文献类型：
--
作者：
Jaeger, J;Goodwin, BC
在本文中，我们提出了一种基于细胞振荡器（CO）的模式形成模型。细胞内的振荡过程作为发育时钟，其周期受到细胞自主或非自主机制的严格调控。当时钟在其周期的不同时间或阶段减速和停止时，细胞振荡的初始时间顺序冻结成空间顺序，从而产生空间模式。我们将CO模型应用于脊椎动物体细胞发生，并表明我们可以重现在体细胞前中胚层中观察到的周期性基因表达模式的动态。我们还展示了如何使用CO模型生成不同的点长度。然后，我们根据实验证据及其与生物模式形成的其他实例的相关性来讨论该模型，显示其作为模式生成器的多功能性。(C) 2001学术出版社。
In this paper, we present a model for pattern formation in developing organisms that is based on cellular oscillators (CO). An oscillatory process within cells serves as a developmental clock whose period is tightly regulated by cell autonomous or non-autonomous mechanisms. A spatial pattern is generated as a result of an initial temporal ordering of the cell oscillators freezing into spatial order as the clocks slow down and stop at different times or phases in their cycles. We apply a CO model to vertebrate somitogenesis and show that we can reproduce the dynamics of periodic gene expression patterns observed in the pre-somitic mesoderm. We also show how varying somite lengths can be generated with the CO model. We then discuss the model in view of experimental evidence and its relevance to other instances of biological pattern formation, showing its versatility as a pattern generator. (C) 2001 Academic Press.