Deferoxamine attenuates white matter injury in a piglet intracerebral hemorrhage model.
Deferoxamine attenuates white matter injury in a piglet intracerebral hemorrhage model.
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DOI：
10.1161/strokeaha.113.003033
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发表时间：
2014-01
期刊：
影响因子：
8.3
通讯作者：
Xi G
中科院分区：
文献类型：
--
作者：
Xie Q;Gu Y;Hua Y;Liu W;Keep RF;Xi G
去铁胺可减少脑出血(ICH)仔猪模型中的神经元死亡。本研究探讨了去铁胺对仔猪血肿周围白质水肿的影响。将自体血液注入仔猪右侧额叶，诱发ICH。在第一部分的研究中，确定了水肿形成的时间进程。第二部分观察去铁胺对脑出血大鼠脑白质水肿、肿瘤坏死因子-α(TN-α)和受体相互作用蛋白激酶1(RIPK-1)的影响。ICH大鼠脑水肿明显，脑白质肿瘤坏死因子-α和RIPK_1水平升高。去铁胺全身治疗可显著降低脑出血后脑白质肿瘤坏死因子-α和RIPK1水平，减轻脑白质水肿。去铁胺可降低仔猪脑出血后脑白质水肿及肿瘤坏死因子-α和RIPK1水平，提示去铁胺是治疗脑出血的一种潜在有效药物。
Deferoxamine reduces neuronal death in a piglet model of intracerebral hemorrhage (ICH). This study examined the effect of deferoxamine on perihematomal white matter edema in piglets. ICH was induced by an injection of autologous blood into the right frontal lobe of piglets. In the first part of study, the time course of edema formation was determined. In the second part, the effects of deferoxamine on ICH-induced white matter edema, tumor necrosis factor-alpha (TNF-α) and receptor-interacting protein kinase 1 (RIPK1) were examined. ICH resulted in marked brain edema and increased TNF-α and RIPK1 levels in white matter. Systemic treatment with deferoxamine markedly reduced white matter TNF-α and RIPK1 levels and attenuated white matter edema after ICH. Deferoxamine reduces white matter edema and TNF-α and RIPK1 levels after ICH in piglets suggesting deferoxamine is a potential effective therapeutic agent for ICH patients.