Recovery of corneal subbasal nerve density after PRK and LASIK
Recovery of corneal subbasal nerve density after PRK and LASIK
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DOI：
10.1016/j.ajo.2005.07.027
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发表时间：
2005-12-01
影响因子：
4.2
通讯作者：
Bourne, WM
中科院分区：
文献类型：
--
作者：
Erie, JC;McLaren, JW;Bourne, WM
目的：测量和比较屈光性角膜切除术 (PRK) 和激光原位角膜磨镶术 (LASIK) 后 5 年内角膜神经支配的恢复情况。设计：前瞻性、非随机临床试验。方法：12 名患者的 18 只眼睛接受了 PRK，以矫正 -3.73 +/- 1.30 屈光度的平均屈光不正，11 名患者的 16 只眼睛接受了 PRK 治疗。激光近视手术 矫正 -6.56 +/- 2.44 屈光度的平均屈光不正。在手术前和手术后 1 年、2 年、3 年和 5 年通过共聚焦显微镜检查角膜。测量基底神经纤维束以确定密度（神经/框架区域的可见长度）并表示为微米/平方毫米。通过 Friedman 检验比较差异，并通过 Student-Newman-Keuls 程序调整多重比较。 结果：PRK 后，与术前 (6786 +/- 1948 mu m/ mm(2)) 相比，1 年时平均基底神经密度降低 59% (2764 +/- 1321 mu m/mm(2) [+/- SD])；P
PURPOSE: To measure and compare the return of corneal innervation up to 5 years after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK).DESIGN: Prospective, nonrandomized clinical trial.METHODS: Eighteen eyes of 12 patients received PRK to correct a mean refractive error of -3.73 +/- 1.30 diopters, and 16 eyes of 11 patients received LASIK to correct a mean refractive error of -6.56 +/- 2.44 diopters. Corneas were examined by confocal microscopy before and at 1, 2, 3, and 5 years after the procedures. Subbasal nerve fiber bundles were measured to determine density (visible length of nerve/frame area) and expressed as micrometers per square millimeters. Differences were compared by Friedman's test and adjusted for multiple comparisons by the Student-Newman-Keuls procedure.RESULTS: After PRK, mean subbasal nerve density was reduced by 59% at 1 year (2764 +/- 1321 mu m/mm(2) [+/- SD]) when compared with preoperative (6786 +/- 1948 mu m/ mm(2); P