Serum carcinoembryonic antigen, neuron-specific enolase as biomarkers for diagnosis of nonsmall cell lung cancer
Serum carcinoembryonic antigen, neuron-specific enolase as biomarkers for diagnosis of nonsmall cell lung cancer
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DOI：
10.4103/0973-1482.191626
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发表时间：
2016-10-01
影响因子：
1.3
通讯作者：
Zhang, Shuanglin
中科院分区：
文献类型：
--
作者：
Dong, Yanjun;Zheng, Xianjie;Zhang, Shuanglin
目的：探讨血清癌胚抗原（CEA）和神经元特异性烯醇化酶（NSE）作为诊断非小细胞肺癌（NSCLC）生物标志物的临床价值。材料和方法：回顾性分析2013年2月至2016年1月我院经细胞学或病理证实的46例非小细胞肺患者和33例良性肺疾病（BLD）患者。荧光法测定血清CEA、NSE浓度。采用SPSS17.0软件分析血清CEA和NSE作为肺癌诊断标志物的敏感性、特异性和受试者工作特征（ROC）曲线下面积（area under curve）。结果如下：血清CEA和NSE浓度在NSCLC组分别为30.69 ± 14.11ng/mL和52.36 ± 49.68ng/mL，在BLD组分别为12.69 ± 8.87ng/mL和5.32 ± 4.66，差异有统计学意义（P < 0.05）;以5.74 ng/mL为界值时，CEA诊断胃癌的敏感性为58.66%，特异性为76.48%;血清NSE的临界值为19.35 ng/mL; CEA和NSE作为NSCLC诊断生物标志物的ROC曲线下面积分别为0.81和0.76。结论：血清CEA和NSE是诊断NSCLC的潜在生物学指标。
Objective: To investigate the clinical efficacy of serum carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) as biomarkers for diagnosis of nonsmall cell lung cancer (NSCLC). Material and Methods: Forty-six cytology or pathology confirmed nonsmall cell lung patients and 33 cases of benign lung disease (BLD) were retrospective reviewed in our hospital from February 2013 to January 2016. The serum concentrations of CEA and NSE were measured by chemiluminescent assay. The sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (area under the curve) of serum CEA and NSE as biomarkers for diagnosis of lung cancer were analyzed by SPSS version 17.0 software. Results: The serum CEA and NSE concentration were 30.69 14.11 ng/mL, 52.36 49.68 ng/mL for NSCLC patients and 12.69 8.87 ng/mL, 5.32 4.66 for BLD patients, respectively with statistical difference (P < 0.05); the diagnostic sensitivity and specificity were 58.66% and 76.48% for serum CEA at the cutoff value of 5.74 ng/mL and 66.67% and 78.69% for serum NSE at the cutoff value of 19.35 ng/mL; the diagnostic area under the ROC curve was 0.81 and 0.76 for CEA and NSE, respectively as biomarkers for diagnosis of NSCLC. Conclusion: Serum CEA and NSE are potential biomarker for NSCLC diagnosis.