Does maternal smoking during pregnancy have a direct effect on future offspring obesity? Evidence from a prospective birth cohort study
Does maternal smoking during pregnancy have a direct effect on future offspring obesity? Evidence from a prospective birth cohort study
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DOI：
10.1093/aje/kwj209
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发表时间：
2006-08-15
影响因子：
5
通讯作者：
Najman, Jake M.
中科院分区：
文献类型：
--
作者：
Al Mamun, Abdullah;Lawlor, Debbie A.;Najman, Jake M.
作者利用 1981 年至 1984 年间出生于澳大利亚布里斯班的 3,253 名儿童（52% 男性）组成的人口出生队列前瞻性研究母亲怀孕期间吸烟是否与后代超重和肥胖有关。作者根据母亲吸烟模式（从不吸烟、怀孕前和/或怀孕后吸烟但怀孕期间不吸烟、或怀孕期间吸烟）比较了后代的平均体重指数（体重（kg）/身高（m）（2））以及 14 岁时的超重和肥胖水平。母亲在怀孕期间吸烟的后代的青少年体重指数以及超重和肥胖的患病率高于母亲从未吸烟的后代。母亲在怀孕期间停止吸烟但在孩子一生中其他时间吸烟的青少年后代的体重指数以及超重和肥胖水平与母亲从未吸烟的后代相似。这些结果独立于一系列潜在的混杂因素，表明母亲在怀孕期间吸烟对青少年超重和肥胖有直接影响。它们为劝说孕妇不要吸烟和鼓励年轻女性永不吸烟提供了另一个激励。
The authors used a population-based birth cohort of 3,253 children (52% males) born in Brisbane, Australia, between 1981 and 1984 to prospectively examine whether maternal smoking during pregnancy was associated with offspring overweight and obesity. The authors compared mean body mass indexes (weight (kg)/height (m)(2)) and levels of overweight and obesity at age 14 years among offspring by patterns of maternal smoking (never smoked, smoked before and/or after pregnancy but not during pregnancy, or smoked during pregnancy). Adolescent body mass index and prevalences of overweight and obesity were greater in offspring whose mothers had smoked during pregnancy than in those whose mothers had never smoked. Body mass index and levels of overweight and obesity among adolescent offspring whose mothers stopped smoking during pregnancy but smoked at other times in the child's life were similar to those among offspring whose mothers had never smoked. These results were independent of a range of potentially confounding factors and suggest a direct effect of maternal smoking during pregnancy on adolescent overweight and obesity. They provide yet another incentive for pregnant women to be persuaded not to smoke and for young women to be encouraged to never take up smoking.