The quantitative relationship between clearance rate constants and number of C1-fixing sites.
The quantitative relationship between clearance rate constants and number of C1-fixing sites.
复制标题
清除率常数与 C1 固定位点数量之间的定量关系。
作者：
N. Meryhew;K. Marsden;O. Runquist
将豚鼠中免疫介导的RBC清除动力学数据相关的速率方程扩展到人体研究。在正常志愿者中评价IgG、IgM和冷凝集素致敏RBC的清除率，以及在一小组原发性胆汁性肝硬化患者中评价IgM致敏细胞的清除率。在敏化红细胞的清除率评价的所有速率常数被发现与C1固定网站的数量。这些相关性不仅提供了额外的支持的机制，从方程的速率推导，但也允许定量预测的速率常数和清除模式的基础上的致敏水平。此外，对异常清除研究数据的分析产生了速率常数，可对特定缺陷反应进行鉴别和定量。
The rate equation correlating kinetic data for immune-mediated clearance of RBC in guinea pigs was extended to human studies. Rate constants were evaluated for clearance of IgG, IgM, and cold agglutinin-sensitized RBC in normal human volunteers as well as for clearance of IgM-sensitized cells from a small group of patients with primary biliary cirrhosis. All rate constants evaluated in the clearance of sensitized RBC were found to correlate with the number of C1-fixing sites. These correlations not only provide additional support for the mechanism from which the rate of equation was derived, but also allow a quantitative prediction of rate constants and clearance patterns based on the level of sensitization. In addition, the analysis of data from abnormal clearance studies produced rate constants that provided both identification and quantification of the specific defective reaction(s).