Prognostic significance of the postoperative level and recovery rate of serum albumin in patients with curatively resected pancreatic ductal adenocarcinoma
Prognostic significance of the postoperative level and recovery rate of serum albumin in patients with curatively resected pancreatic ductal adenocarcinoma
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DOI：
10.3892/mco.2019.1883
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发表时间：
2019-09-01
影响因子：
1.2
通讯作者：
Kitagawa, Yuko
中科院分区：
文献类型：
--
作者：
Nakano, Yutaka;Kitago, Minoru;Kitagawa, Yuko
本研究的目的是调查根治性切除的胰腺导管腺癌（PDAC）患者的临床病理特征和与术前和术后血清白蛋白水平相关的预后因素。为此，我们回顾性分析了1995年1月至2016年3月期间因PDAC而接受胰腺切除术的患者的数据，并评估了术后第3、6和12个月（POM）的术前和术后血清白蛋白水平。还调查了血清白蛋白回收率。共有 196 名患者参加了本研究。多因素Cox回归分析中，淋巴结转移[风险比（HR）：1.65； P=0.022]、POM 12 时的血清白蛋白水平（>= 3.9 g/dl；HR：0.60；P=0.017）和 POM 12 时的血清白蛋白恢复率（>= 1.00；HR：0.60；P=0.017）是无病生存的独立预后因素。淋巴结转移（HR：1.79；P=0.013）和POM 12时血清白蛋白水平（>= 3.9 g/dl）（HR：0.60；P=0.033）是总生存的独立预后因素。这些结果表明术后血清白蛋白水平和恢复率是预测根治性切除PDAC患者预后的潜在生物标志物。然而，需要进一步的研究来调查增加术后血清白蛋白水平对这些患者的生存益处。
The aim of the present study was to investigate the clinicopathological features and prognostic factors associated with pre- and postoperative serum albumin levels in patients with curatively resected pancreatic ductal adenocarcinoma (PDAC). To achieve this, the data of patients who underwent pancreatectomy for PDAC between January 1995 and March 2016 were retrospectively reviewed, and the pre- and postoperative serum albumin levels at postoperative months (POMs) 3, 6, and 12 were evaluated. The serum albumin recovery rate was also investigated. A total of 196 patients were enrolled in the present study. In the multivariate Cox regression analysis, lymph node metastasis [hazard ratio (HR): 1.65; P=0.022], serum albumin level at POM 12 (>= 3.9 g/dl; HR: 0.60; P=0.017), and serum albumin recovery rate at POM 12 (>= 1.00; HR: 0.60; P=0.017) were independent prognostic factors for disease-free survival. Lymph node metastasis (HR: 1.79; P=0.013) and serum albumin level at POM 12 (>= 3.9 g/dl) (HR: 0.60; P=0.033) were independent prognostic factors for overall survival. These results indicated that the postoperative level and recovery rate of serum albumin are potential biomarkers for predicting the prognosis of patients with curatively resected PDAC. However, further studies are required in order to investigate the survival benefit of increasing postoperative serum albumin levels in these patients.