Favorable prognostic impact of Natural Killer cells and T cells in high-grade serous ovarian carcinoma
Favorable prognostic impact of Natural Killer cells and T cells in high-grade serous ovarian carcinoma
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DOI：
10.1080/0284186x.2019.1711173
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发表时间：
2020-01-13
期刊：
影响因子：
3.1
通讯作者：
Steffensen, Karina Dahl
中科院分区：
文献类型：
--
作者：
Henriksen, Jon Roikjaer;Donskov, Frede;Steffensen, Karina Dahl
简介：本研究的目的是研究肿瘤内细胞毒性T细胞、自然杀伤（NK）细胞、中性粒细胞和PD-L1表达对上皮性卵巢癌患者预后的影响。方法：2005年丹麦所有诊断为高级别浆液性癌（HGSC）的患者均纳入本研究。对来自283名患者的肿瘤组织进行PD-L1、CD 8、CD 66 b和CD 57的免疫组织化学染色。使用数字图像分析方法分析细胞密度。主要终点为总生存期（OS）。结果：HGSC患者的中位OS为30个月。高水平CD 57 + NK细胞（>= 10 cells/mm（2））患者的生存期为45个月，而低水平患者为29个月（
Introduction: The aim of the present study was to investigate the prognostic impact of intratumoral cytotoxic T cells, Natural Killer (NK) cells, neutrophils and PD-L1 expression in patients with epithelial ovarian cancer. Methods: All patients diagnosed with high-grade serous carcinoma (HGSC) in Denmark in 2005 were included in the study. Immunohistochemical staining for PD-L1, CD8, CD66b and CD57 was performed on tumor tissue from 283 patients. Cell densities were analyzed using a digital image analysis method. The primary endpoint was overall survival (OS). Results: The median OS for HGSC patients was 30 months. It was 45 months in patients with high level of CD57+ NK cells (>= 10 cells/mm(2)) compared with 29 month in patients with low level (