Readers, writers, and erasers: chromatin as the whiteboard of heart disease.
Readers, writers, and erasers: chromatin as the whiteboard of heart disease.
复制标题
DOI：
10.1161/circresaha.116.303630
复制
发表时间：
2015-03-27
影响因子：
20.1
通讯作者：
Hill JA
中科院分区：
文献类型：
--
作者：
Gillette TG;Hill JA
将DNA动态包装到核小体序列中是真核细胞调节基因表达的主要机制。核小体结构和组装的复杂控制控制着RNA聚合酶II对DNA的访问以及随后的RNA合成。作为这一过程的一部分，组蛋白的翻译后修饰是染色质结构调节的核心，在调节基因转录的激活和抑制方面发挥着至关重要的作用。在心脏，组蛋白修饰的动态动态平衡-由修饰物的作用和下游效应物的招募-是在疾病相关应激的背景下发生的转录重编程的基本调节因素。在这里，我们检查越来越多的证据表明，组蛋白修饰是心肌病理性生长和重塑的关键机制。
Dynamic packaging of DNA into strings of nucleosomes is a major mechanism whereby eukaryotic cells regulate gene expression. Intricate control of nucleosomal structure and assembly governs access of RNA polymerase II to DNA and consequent RNA synthesis. As part of this, post-translational modifications of histone proteins are central to the regulation of chromatin structure, playing vital roles in regulating the activation and repression of gene transcription. In the heart, dynamic homeostasis of histone modification – driven by the actions of modifiers and recruitment of downstream effectors – is a fundamental regulator of the transcriptional reprogramming that occurs in the setting of disease-related stress. Here, we examine the growing evidence for histone modification as a key mechanism governing pathological growth and remodeling of the myocardium.