Cortical local circuit axons do not mature after early deafferentation.
Cortical local circuit axons do not mature after early deafferentation.
复制标题
早期传入神经阻滞后，皮质局部回路轴突并不成熟。
DOI：
10.1073/pnas.89.5.1832
复制
发表时间：
1992
影响因子：
11.1
通讯作者：
Woolsey,TA
中科院分区：
文献类型：
--
作者：
McCasland,JS;Bernardo,KL;Probst,KL;Woolsey,TA
对于哺乳动物大脑功能至关重要的皮质内连接的发育、完善和保留的过程尚不清楚。通过自动图像分析对小鼠体感桶状皮层中辣根过氧化物酶标记的纤维进行了评估，该纤维的图案类似于对侧面部的胡须，它从中接收输入。胡须的感觉神经在出生后第 7 天、胡须图确定后被切断。对成年人进行的检查显示，与正常对照组相比，被剥夺的桶状皮层的皮质内投射大大减少，尽管皮层中胡须的地图没有变化。这从解剖学上证明了皮质内连接的正常模式，就像正常的感觉图一样，取决于四个突触外的感觉外围。
The processes underlying development, refinement, and retention of the intracortical connections critical for the function of the mammalian brain are unknown. Horseradish peroxidase-labeled fibers in mouse somatosensory barrel cortex, which is patterned like the whiskers on the contralateral face from which it receives inputs, were evaluated by automated image analysis. The sensory nerve to the whiskers was sectioned on postnatal day 7, after the whisker map is set. The deprived barrel cortices, examined in adults, showed drastically diminished intracortical projections relative to normal controls, although the map of the whiskers in the cortex was unchanged. This demonstrates anatomically that the normal pattern of intracortical connections, like the normal sensory map, is dependent upon the sensory periphery four synapses away.