Overview: toward a dysregulation hypothesis of depression.
Overview: toward a dysregulation hypothesis of depression.
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概述：抑郁症的失调假说。
DOI：
10.1176/ajp.142.9.1017
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
K. Davis
中科院分区：
文献类型：
--
作者：
L. Siever;K. Davis
作者认为，情感障碍和相关精神病综合征中神经递质系统的活动可能更好地理解为反映了其调节的相对失败，而不是简单的活动增加或减少。围绕“失调”概念组织的模型假定，一种或多种神经递质稳态调节机制的持续损伤赋予了对不稳定或不稳定的神经递质输出的特质脆弱性。从临床和动物模型研究的证据去甲肾上腺素能系统在抑郁症的失调检查相对于这样一个一般模型产生的标准，并提出了一个具体的配置去甲肾上腺素能失调在某些形式的抑郁症。
The authors suggest that the activity of neurotransmitter systems in the affective disorders and related psychiatric syndromes may be better understood as a reflection of a relative failure in their regulation, rather than as simple increases or decreases in their activity. A model organized around the concept of "dysregulation" posits that persistent impairment in one or more neurotransmitter homeostatic regulatory mechanisms confers a trait vulnerability to unstable or erratic neurotransmitter output. Evidence from clinical and animal model studies for dysregulation of the noradrenergic system in depression is examined with respect to criteria generated by such a general model, and a specific configuration of noradrenergic dysregulation in some forms of depression is proposed.